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Cellosaurus Hep-G2/2.2.1 (CVCL_3701)

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Cell line name Hep-G2/2.2.1
Synonyms HEP-G2/2.2.1; HEP G2/2.2.1; HepG2/2.2.1; Hep 2.2.1
Accession CVCL_3701
Resource Identification Initiative To cite this cell line use: Hep-G2/2.2.1 (RRID:CVCL_3701)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11997.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-11997

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811,12
D7S82010
D13S3179,13
D16S53912,13
TH019
TPOX8,9
vWA17

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Publications

Patent=US5821057
John Young-Ling Chiang, Diane Stroup;
Assay for agents that affect cholesterol 7alpha-hydroxylase expression and a characterization of its regulatory elements.
Patent number US5821057, 13-Oct-1998

Cross-references
Cell line collections (Providers) ATCC; CRL-11997 - Discontinued
BCRC; 60364
Cell line databases/resources CLO; CLO_0003705
cancercelllines; CVCL_3701
Anatomy/cell type resources BTO; BTO_0004572
Encyclopedic resources Wikidata; Q54882786
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number28