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Cellosaurus HBE4-E6/E7 (CVCL_3696)

[Text version]
Cell line name HBE4-E6/E7
Synonyms HBE4-E6E7; NBE4-E6/E7
Accession CVCL_3696
Resource Identification Initiative To cite this cell line use: HBE4-E6/E7 (RRID:CVCL_3696)
Comments Population: Caucasian.
Doubling time: ~24 hours (ATCC=CRL-2078).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Variations; SNP array analysis.
Donor information: Established from a patient undergoing left upper lobectomy for a poorly differentiated adenocarcinoma (PubMed=8174640).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3697 (HBE4-E6/E7-C1)
Sex of cell Male
Age at sampling 60Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-2078

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817
D3S135816,17
D5S81810,11
D7S82010,11
D8S117913,14
D13S31711
D16S53911,13
D18S5116,18
D19S43315.2,16.2
D21S1133.2
FGA21,25
Penta D12
Penta E5,13
TH016,8
TPOX8
vWA14,17

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Publications

PubMed=8174640; DOI=10.1006/excr.1994.1115
Viallet J., Liu C., Emond J., Tsao M.-S.
Characterization of human bronchial epithelial cells immortalized by the E6 and E7 genes of human papillomavirus type 16.
Exp. Cell Res. 212:36-41(1994)

PubMed=8601403; DOI=10.1006/excr.1996.0081
Tsao M.-S., Zhu H., Viallet J.
Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells.
Exp. Cell Res. 223:268-273(1996)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2078
Cell line databases/resources CLO; CLO_0003624
cancercelllines; CVCL_3696
Biological sample resources BioSample; SAMN03471436
Encyclopedic resources Wikidata; Q54881380
Gene expression databases GEO; GSM827168
Polymorphism and mutation databases Progenetix; CVCL_3696
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19