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Cellosaurus HBE4-E6/E7 (CVCL_3696)

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Cell line name HBE4-E6/E7
Synonyms HBE4-E6E7; NBE4-E6/E7
Accession CVCL_3696
Resource Identification Initiative To cite this cell line use: HBE4-E6/E7 (RRID:CVCL_3696)
Comments Population: Caucasian.
Doubling time: ~24 hours (ATCC=CRL-2078).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Variations; SNP array analysis.
Donor information: Established from a patient undergoing left upper lobectomy for a poorly differentiated adenocarcinoma (PubMed=8174640).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3697 (HBE4-E6/E7-C1)
Sex of cell Male
Age at sampling 60Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-2078

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817
D3S135816,17
D5S81810,11
D7S82010,11
D8S117913,14
D13S31711
D16S53911,13
D18S5116,18
D19S43315.2,16.2
D21S1133.2
FGA21,25
Penta D12
Penta E5,13
TH016,8
TPOX8
vWA14,17

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Publications

PubMed=8174640; DOI=10.1006/excr.1994.1115
Jean Viallet, Chi Liu, Jaqueline Emond, Ming-Sound Tsao;
Characterization of human bronchial epithelial cells immortalized by the E6 and E7 genes of human papillomavirus type 16.
Exp. Cell Res. 212:36-41(1994)

PubMed=8601403; DOI=10.1006/excr.1996.0081
Ming-Sound Tsao, Hong Zhu, Jean Viallet;
Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells.
Exp. Cell Res. 223:268-273(1996)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2078
Cell line databases/resources CLO; CLO_0003624
cancercelllines; CVCL_3696
Biological sample resources BioSample; SAMN03471436
Encyclopedic resources Wikidata; Q54881380
Gene expression databases GEO; GSM827168
Polymorphism and mutation databases Progenetix; CVCL_3696
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19