ID   HBE4-E6/E7
AC   CVCL_3696
SY   HBE4-E6E7; NBE4-E6/E7
DR   CLO; CLO_0003624
DR   ATCC; CRL-2078
DR   BioSample; SAMN03471436
DR   cancercelllines; CVCL_3696
DR   GEO; GSM827168
DR   Progenetix; CVCL_3696
DR   Wikidata; Q54881380
RX   PubMed=8174640;
RX   PubMed=8601403;
RX   PubMed=20215515;
CC   Population: Caucasian.
CC   Doubling time: ~24 hours (ATCC=CRL-2078).
CC   Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
ST   Source(s): ATCC=CRL-2078
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,13
ST   D18S51: 16,18
ST   D19S433: 15.2,16.2
ST   D21S11: 33.2
ST   D2S1338: 17
ST   D3S1358: 16,17
ST   D5S818: 10,11
ST   D7S820: 10,11
ST   D8S1179: 13,14
ST   FGA: 21,25
ST   Penta D: 12
ST   Penta E: 5,13
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 17
//
RX   PubMed=8174640; DOI=10.1006/excr.1994.1115;
RA   Viallet J., Liu C., Emond J., Tsao M.-S.;
RT   "Characterization of human bronchial epithelial cells immortalized by
RT   the E6 and E7 genes of human papillomavirus type 16.";
RL   Exp. Cell Res. 212:36-41(1994).
//
RX   PubMed=8601403; DOI=10.1006/excr.1996.0081;
RA   Tsao M.-S., Zhu H., Viallet J.;
RT   "Autocrine growth loop of the epidermal growth factor receptor in
RT   normal and immortalized human bronchial epithelial cells.";
RL   Exp. Cell Res. 223:268-273(1996).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//