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Cellosaurus J558 (CVCL_3529)

[Text version]
Cell line name J558
Accession CVCL_3529
Resource Identification Initiative To cite this cell line use: J558 (RRID:CVCL_3529)
Comments Problematic cell line: Potentially contaminated. The stock distributed by ATCC (TIB-6) has a STR profile that matches at 95% with that of BALB/3T3 clone A31 (Cellosaurus=CVCL_0184). As this is the parent cell line to a cell line J558L (Cellosaurus=CVCL_3949) which is used a fusion cell line for the production of hybridomas ICLAC is currently investigating if authentic stocks of J558 still exist.
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Monoclonal antibody isotype: IgA, lambda.
Monoclonal antibody target: ChEBI; CHEBI_52071; Dextran.
Cell type: Plasma cell; CL=CL_0000786.
Disease Mouse multiple myeloma (NCIt: C125417)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Children:
CVCL_E3HM (HyCyte J558-Luc)CVCL_3949 (J558L)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=31220119

Markers:
Mouse STR 1-116
Mouse STR 1-217
Mouse STR 2-116
Mouse STR 3-214
Mouse STR 4-221.3
Mouse STR 5-514
Mouse STR 6-418
Mouse STR 6-712
Mouse STR 7-125.2
Mouse STR 8-113
Mouse STR 11-217
Mouse STR 12-116
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-216
Mouse STR 18-318
Mouse STR 19-214
Mouse STR X-125

Run an STR similarity search on this cell line
Publications

PubMed=5483159; DOI=10.1038/2281045a0
Martin G. Weigert, Italo M. Cesari, Shirlee J. Yonkovich, Melvin Cohn;
Variability in the lambda light chain sequences of mouse antibody.
Nature 228:1045-1047(1970)

PubMed=6157734; DOI=10.4049/jimmunol.125.4.1454
Nirmala Bhoopalam, Paul Heller, Naomi Meyerstein, Lemuel Hall;
Effect of dextran-S (alpha, 1-3 dextran) on the growth of plasmacytomas MOPC-104E and J558.
J. Immunol. 125:1454-1458(1980)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Jamie L. Almeida, Aleksandra Dakic, Karin Kindig, Maikan Kone, Deborah Lee Dormady Letham, Scott Langdon, Ruth Peat, Jayamalini Holding-Pillai, Erin M. Hall, Mark Ladd, Megan D. Shaffer ...Show all 23 authors... , Heath Berg, Jin-Liang Li, Georges Wigger, Steve Lund, Carolyn R. Steffen, Barbara B. Fransway, Bob Geraghty, Manuela Natoli, Beth A. Bauer, Susanne M. Gollin, Dale W. Lewis, Yvonne A. Reid; Show fewer authors
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:e0218412.1-e0218412.24(2019)

Cross-references
Cell line collections (Providers) ATCC; TIB-6
Cell line databases/resources CLO; CLO_0007001
Biological sample resources BioSample; SAMN11397662 - Discontinued
Encyclopedic resources Wikidata; Q28243888
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number17