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Cellosaurus MuM-2C (CVCL_3448)

[Text version]
Cell line name MuM-2C
Synonyms MUM-2C; MUM2C; Mum2C
Accession CVCL_3448
Resource Identification Initiative To cite this cell line use: MuM-2C (RRID:CVCL_3448)
Comments Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with metastatic uveal melanoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00501.
Population: Caucasian.
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0001CCC000232). It was one of the sources for the STR profile of this entry.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1395 (M14)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=18689700

Markers:
AmelogeninX
CSF1PO11
D2S133819
D3S135814,16
D5S81811,12
D7S8208,10
D8S117913
D13S31712
D16S5399
D18S5113,18
D19S43314,15
D21S1130
FGA21
TH016,7
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12067204; DOI=10.1023/A:1015591624171
Elisabeth A. Seftor, Paul S. Meltzer, Dawn A. Kirschmann, Jacob Pe'er, Andrew J. Maniotis, Jeffrey M. Trent, Robert Folberg, Mary J.C. Hendrix;
Molecular determinants of human uveal melanoma invasion and metastasis.
Clin. Exp. Metastasis 19:233-246(2002)

PubMed=15299072; DOI=10.1158/1535-7163.895.3.8
Jian-Zhong Qin, Lawrence Stennett, Patricia Bacon, Barbara Bodner, Mary J.C. Hendrix, Richard E.B. Seftor, Elisabeth A. Seftor, Naira V. Margaryan, Pamela M. Pollock, Amy Curtis, Jeffrey M. Trent ...Show all 14 authors... , Frank Bennett, Lucio Miele, Brian J. Nickoloff; Show fewer authors
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
Mol. Cancer Ther. 3:895-902(2004)

PubMed=18689700; DOI=10.1167/iovs.08-2324; PMCID=PMC2576485
Robert Folberg, ShriHari S. Kadkol, Shahar Frenkel, Klara Valyi-Nagy, Martine Johanna Jager, Jacob Pe'er, Andrew J. Maniotis;
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Klaus Georg Griewank, Xiao-Xing Yu, Jahan S. Khalili, Mustafa Mert Sozen, Katherine Stemke-Hale, Chantale Bernatchez, Seth Wardell, Boris C. Bastian, Scott E. Woodman;
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=28940260; DOI=10.1002/ijc.31067; PMCID=PMC5762610
Christopher T. Korch, Erin M. Hall, Wilhelm Gerhard Dirks, Margaret Ewing, Mark Faries, Marileila Varella-Garcia, Steven Robinson, Douglas R. Storts, Jacqueline A. Turner, Ying Wang, Edward C. Burnett ...Show all 18 authors... , Lyn E. Healy, Douglas A. Kniss, Richard M. Neve, Raymond Whiting Nims, Yvonne A. Reid, William A. Robinson, Amanda Capes-Davis; Show fewer authors
Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.
Int. J. Cancer 142:561-572(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3448
Anatomy/cell type resources BTO; BTO_0005299
Encyclopedic resources Wikidata; Q54907076
Polymorphism and mutation databases Cosmic; 1628412
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28