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Cellosaurus NT2-D1 (CVCL_3407)

[Text version]
Cell line name NT2-D1
Synonyms NT2/D1; NT2D1; Nt2D1; NTERA-2 clone D1; NTERA2-cloneD1; NTERA-2 cl.D1; NTera2 cl.D1; NTERA-2cl.D1; NTera 2/cl.D1; NTERA2CLD1; NTERA-2/D1; NTera2/D1; NTERA2-D1; NTera-2D1; Ntera2/D1; NTERA2/D1; NTERA2D1; NTera2D1; Tera
Accession CVCL_3407
Resource Identification Initiative To cite this cell line use: NT2-D1 (RRID:CVCL_3407)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: NTERA-S-cl-D1; ArrayExpress=E-MTAB-783; CLO=CLO_0037150; Cosmic=1995598.
Misspelling: NTL-D1; Cosmic=2077191.
Misspelling: NT2101; Cosmic=2163756; PubMed=24812411.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.45
East Asian, South1.42
South Asian4.09
European, North53.03
European, South39.23
Disease Embryonal carcinoma (NCIt: C3752)
Embryonal carcinoma (ORDO: Orphanet_180226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0034 (NTERA-2)
CVCL_7929 (NT2-N)CVCL_A5AF (Tera-CP)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC

Penta D12,13
Penta E5,14

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/NTERA-2

PubMed=6144603; DOI=10.1016/0012-1606(84)90316-6
Andrews P.W.
Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
Dev. Biol. 103:285-293(1984)

Andrews P.W., Damjanov I., Simon D., Banting G.S., Carlin C.R., Dracopoli N.C., Fogh J.
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
Lab. Invest. 50:147-162(1984)

PubMed=3293662; DOI=10.1016/0304-419X(88)90003-0
Andrews P.W.
Human teratocarcinomas.
Biochim. Biophys. Acta 948:17-36(1988)

Timmer-Bosscha H., Timmer A., Meijer C., de Vries E.G.E., de Jong B., Oosterhuis J.W., Mulder N.H.
cis-diamminedichloroplatinum(ii) resistance in vitro and in vivo in human embryonal carcinoma cells.
Cancer Res. 53:5707-5713(1993)

PubMed=8411264; DOI=10.1002/jnr.490350603
Pleasure S.J., Lee V.M.-Y.
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
J. Neurosci. Res. 35:585-602(1993)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868
Feldman D.R., Iyer G., Van Alstine L., Patil S., Al-Ahmadie H., Reuter V.E., Bosl G.J., Chaganti R.S.K., Solit D.B.
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clin. Cancer Res. 20:3712-3720(2014)

PubMed=25802994; DOI=10.1177/026119291504300105
Jasnic-Savovic J., Klajn A., Milivojevic M., Mojsin M., Nikcevic G.
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation.
Altern. Lab. Anim. 43:9-18(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) ATCC; CRL-1973
BCRC; 60356
BCRJ; 0303
ECACC; 01071221
ICLC; HTL97025
Cell line databases/resources CLO; CLO_0008207
CLO; CLO_0037150
CLDB; cl3740
CLDB; cl5088
cancercelllines; CVCL_3407
Cell_Model_Passport; SIDM01203
Cosmic-CLP; 908454
DepMap; ACH-002291
FCS-free; 172-2-320-1-3-3
Lonza; 1094
Anatomy/cell type resources BTO; BTO:0000946
Biological sample resources ENCODE; ENCBS374ENC
Chemistry resources ChEMBL-Cells; CHEMBL3307482
ChEMBL-Targets; CHEMBL614206
GDSC; 908454
PharmacoDB; NTERASclD1_1169_2019
PubChem_Cell_line; CVCL_3407
Encyclopedic resources Wikidata; Q54931100
Experimental variables resources EFO; EFO_0005236
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM824855
GEO; GSM824856
GEO; GSM1040297
GEO; GSM1040367
GEO; GSM1670285
Polymorphism and mutation databases Cosmic; 687052
Cosmic; 908454
Cosmic; 1995598
Cosmic; 2077191
Cosmic; 2163756
IARC_TP53; 21589
IARC_TP53; 21590
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number40