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Cellosaurus NT2-D1 (CVCL_3407)

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Cell line name NT2-D1
Synonyms NT2/D1; NT2D1; Nt2D1; NTERA-2 clone D1; NTERA2-cloneD1; NTERA-2 cl.D1; NTera2 cl.D1; NTERA-2cl.D1; NTera 2/cl.D1; NTERA2CLD1; NTERA-2/D1; NTera2/D1; NTERA2-D1; NTera-2D1; Ntera2/D1; NTERA2/D1; NTERA2D1; NTera2D1; Tera
Accession CVCL_3407
Resource Identification Initiative To cite this cell line use: NT2-D1 (RRID:CVCL_3407)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Misspelling: NTERA-S-cl-D1; ArrayExpress=E-MTAB-783; CLO=CLO_0037150; Cosmic=1995598.
Misspelling: NTL-D1; Cosmic=2077191.
Misspelling: NT2101; Cosmic=2163756; PubMed=24812411.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.78
Native American0
East Asian, North0.45
East Asian, South1.42
South Asian4.09
European, North53.03
European, South39.23
Disease Embryonal carcinoma (NCIt: C3752)
Embryonal carcinoma (ORDO: Orphanet_180226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0034 (NTERA-2)
Children:
CVCL_7929 (NT2-N)CVCL_A5AF (Tera-CP)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1973; Cosmic-CLP=908454; ECACC=01071221

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822,25
D3S135816
D5S8189,12
D7S82010,12
D8S117913,15
D13S31713
D16S53911,12,13
D18S5114
D19S43314,15.2
D21S1130,31
FGA23
Penta D12,13
Penta E5,14
TH019.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/NT2-D1_protocol.pdf
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-113.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/NTERA-2
Publications

PubMed=6144603; DOI=10.1016/0012-1606(84)90316-6
Peter W. Andrews;
Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
Dev. Biol. 103:285-293(1984)

PubMed=6694356
Peter W. Andrews, Ivan Damjanov, Daniela Simon, George Spencer Banting, Cathleen R. Carlin, Nicholas C. Dracopoli, Jorgen Fogh;
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
Lab. Invest. 50:147-162(1984)

PubMed=3293662; DOI=10.1016/0304-419X(88)90003-0
Peter W. Andrews;
Human teratocarcinomas.
Biochim. Biophys. Acta 948:17-36(1988)

PubMed=8242627
Hetty Timmer-Bosscha, Albertus Timmer, Coby Meijer, Elisabeth Geertruida Emma de Vries, Bauke de Jong, J. Wolter Oosterhuis, Nanno H. Mulder;
Cis-diamminedichloroplatinum(ii) resistance in vitro and in vivo in human embryonal carcinoma cells.
Cancer Res. 53:5707-5713(1993)

PubMed=8411264; DOI=10.1002/jnr.490350603
Samuel J. Pleasure, Virginia Man-Yee Lee;
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
J. Neurosci. Res. 35:585-602(1993)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher ...Show all 13 authors... , Barbara Jane Wold, Richard M. Myers; Show fewer authors
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868
Darren R. Feldman, Gopa Iyer, Lindsay Van Alstine, Sujata Patil, Hikmat Al-Ahmadie, Victor E. Reuter, George J. Bosl, Raju S.K. Chaganti, David B. Solit;
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clin. Cancer Res. 20:3712-3720(2014)

PubMed=25802994; DOI=10.1177/026119291504300105
Jovana Jasnic-Savovic, Andrijana Klajn, Milena Milivojevic, Marija Mojsin, Gordana Nikcevic;
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation.
Altern. Lab. Anim. 43:9-18(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1973
BCRC; 60356
BCRJ; 0303
ECACC; 01071221
ICLC; HTL97025
IZSLER; BS TCL 204
Cell line databases/resources CLO; CLO_0008207
CLO; CLO_0037150
CLDB; cl3740
CLDB; cl5088
cancercelllines; CVCL_3407
Cell_Model_Passport; SIDM01203
Cosmic-CLP; 908454
DepMap; ACH-002291
FCS-free; 172-2-320-1-3-3
LINCS_LDP; LCL-1901
Lonza; 1094
Anatomy/cell type resources BTO; BTO_0000946
Biological sample resources ENCODE; ENCBS374ENC
ENCODE; ENCBS578HFO
ENCODE; ENCBS631LTU
ENCODE; ENCBS810EWQ
Chemistry resources ChEMBL-Cells; CHEMBL3307482
ChEMBL-Targets; CHEMBL614206
GDSC; 908454
PharmacoDB; NTERASclD1_1169_2019
PubChem_Cell_line; CVCL_3407
Encyclopedic resources Wikidata; Q54931100
Experimental variables resources EFO; EFO_0005236
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM824855
GEO; GSM824856
GEO; GSM1040297
GEO; GSM1040367
GEO; GSM1670285
Polymorphism and mutation databases Cosmic; 687052
Cosmic; 908454
Cosmic; 1995598
Cosmic; 2077191
Cosmic; 2163756
IARC_TP53; 21589
IARC_TP53; 21590
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43