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Cellosaurus NTERA-2 (CVCL_0034)

[Text version]
Cell line name NTERA-2
Synonyms NTera-2; Ntera-2; NTera 2; NTERA2; NTera2; N-Tera-2; NT-2; NT2
Accession CVCL_0034
Resource Identification Initiative To cite this cell line use: NTERA-2 (RRID:CVCL_0034)
Comments Part of: Human Protein Atlas, Cell Atlas panel.
Population: Caucasian.
Doubling time: ~50-60 hours (DSMZ=ACC-527).
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
HLA typing Source: PubMed=16919167
Class I
HLA-AA*01
HLA-BB*08
HLA-CC*07
Class II
HLA-DQDQB1*02
HLA-DRDRB1*03
DRB3*01

Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*08:01,37:04
HLA-CC*07:01,07:01
Class II
HLA-DRDRB1*03:01,14:76
Disease Embryonal carcinoma (NCIt: C3752)
Embryonal carcinoma (ORDO: Orphanet_180226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2777 (Tera-2)
Children:
CVCL_4U33 (NT2-B9)CVCL_3407 (NT2-D1)CVCL_4U27 (NT2-D3)
CVCL_K047 (NT2-Rho0)CVCL_C0QJ (NTERA-2-R)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-527; PubMed=16919167; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822,25
D3S135816
D5S8189,12
D7S82010,12
D8S117913,15
D13S31713
D16S53911,12,13
D18S5114
D19S43314
D21S1130,31
FGA23
Penta D12,13
Penta E5,14
TH019.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; Wikipedia; -; https://en.wikipedia.org/wiki/NTERA-2
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/other-bladder-cervical/nt2-ntera-2-xenograft-model/
Publications

PubMed=6694356
Peter W. Andrews, Ivan Damjanov, Daniela Simon, George Spencer Banting, Cathleen R. Carlin, Nicholas C. Dracopoli, Jorgen Fogh;
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
Lab. Invest. 50:147-162(1984)

PubMed=3293662; DOI=10.1016/0304-419X(88)90003-0
Peter W. Andrews;
Human teratocarcinomas.
Biochim. Biophys. Acta 948:17-36(1988)

PubMed=16919167; DOI=10.1186/1741-7007-4-28; PMCID=PMC1601965
Richard Josephson, Gregory R. Sykes, Ying Liu, Carol J. Ording, Wei-Ning Xu, Xian-Min Zeng, Soojung Shin, Jeanne Frances Loring, Anirban Maitra, Mahendra Surendra Rao, Jonathan M. Auerbach;
A molecular scheme for improved characterization of human embryonic stem cell lines.
BMC Biol. 4:28.1-28.13(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=35084545; DOI=10.1007/s00345-022-03936-1; PMCID=PMC8921118
Alexander Fichtner, Hanibal Bohnenberger, Omar Elakad, Annika Richter, Christof Lenz, Christoph Oing, Philipp Strobel, Stefan Kueffer, Daniel Nettersheim, Felix Bremmer;
Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry.
World J. Urol. 40:373-383(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-527
IBRC; C10509
RSCB; RSCB0150
Cell line databases/resources CLO; CLO_0008208
CCRID; 1101HUM-PUMC000019
DSMZCellDive; ACC-527
Anatomy/cell type resources BTO; BTO_0000891
Biological sample resources BioSample; SAMN03472969
Chemistry resources ChEMBL-Cells; CHEMBL3308505
ChEMBL-Targets; CHEMBL614205
PharmacoDB; NTERA2_1167_2019
PubChem_Cell_line; CVCL_0034
Encyclopedic resources Wikidata; Q17092091
Experimental variables resources EFO; EFO_0002959
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM7701436
GEO; GSM7701437
Polymorphism and mutation databases Cosmic; 821809
Cosmic; 2439936
Cosmic; 2560242
Cosmic; 2806394
Cosmic; 2807075
Proteomic databases PRIDE; PXD030251
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number33