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Cellosaurus HCC3153 (CVCL_3377)

[Text version]
Cell line name HCC3153
Synonyms HCC 3153; HCC-3153; Hamon Cancer Center 3153
Accession CVCL_3377
Resource Identification Initiative To cite this cell line use: HCC3153 (RRID:CVCL_3377)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JWGray breast cancer cell line panel.
Doubling time: 72.26 hours (JWGray panel).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Gene fusion; HGNC; 290; GRK3 + HGNC; 29435; WWC1; Name(s)=WWC1-GRK3, WWC1-ADRBK2; Note=In frame (PubMed=22032724).
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Thr276Alafs*14 (c.815_824dupAGCCATGTGG); ClinVar=VCV000055723; Zygosity=Unspecified (PubMed=22032724).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*34:02,34:02
HLA-BB*08:01,15:03
HLA-CC*07:01,02:02
Class II
HLA-DQDQB1*06:04,06:04
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=20679594; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133820
D3S135816
D5S81811
D7S8209,10
D8S117913
D13S3179
D16S53911
D18S5117
D19S43312,14.2
D21S1128,32
FGA19
Penta D2.2,5
Penta E7,13
TH019
TPOX8
vWA13,16

Run an STR similarity search on this cell line
Web pages http://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=19582160; DOI=10.1371/journal.pone.0006146
Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:E6146-E6146(2009)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=21778573; DOI=10.3233/BD-2010-0307
Chavez K.J., Garimella S.V., Lipkowitz S.
Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.
Breast Dis. 32:35-48(2010)

PubMed=22032724; DOI=10.1186/1755-8794-4-75
Ha K.C.H., Lalonde E., Li L.-L., Cavallone L., Natrajan R., Lambros M.B., Mitsopoulos C., Hakas J., Kozarewa I., Fenwick K., Lord C.J., Ashworth A., Vincent-Salomon A., Basik M., Reis-Filho J.S., Majewski J., Foulkes W.D.
Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.
BMC Med. Genomics 4:75.1-75.13(2011)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020
Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line databases/resources CLO; CLO_0009910
cancercelllines; CVCL_3377
DepMap; ACH-002324
LINCS_HMS; 51094
LINCS_LDP; LCL-2075
Biological sample resources BioSample; SAMN03470870
Chemistry resources PharmacoDB; HCC3153_498_2019
Encyclopedic resources Wikidata; Q54881686
Experimental variables resources EFO; EFO_0001179
Gene expression databases ArrayExpress; E-TABM-157
GEO; GSM350507
GEO; GSM1053691
GEO; GSM1172966
GEO; GSM1172874
GEO; GSM3145709
Polymorphism and mutation databases Cosmic; 1136375
Cosmic; 1176634
Progenetix; CVCL_3377
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number31