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Cellosaurus BGC-823 (CVCL_3360)

[Text version]
Cell line name BGC-823
Synonyms BGC823
Accession CVCL_3360
Resource Identification Initiative To cite this cell line use: BGC-823 (RRID:CVCL_3360)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (CCRID; PubMed=26116706; PubMed=28851942). Originally thought to be a gastric adenocarcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00570.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteomics; 2DE.
Omics: Transcriptomics; Microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000062, 3131C0001000700011). They were one of the sources for the STR profile of this entry.
Misspelling: BSG823; Note=Occasionally.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Genome ancestry Source: PubMed=30894373

Origin% genome
African65.99
Native American0.77
East Asian, North2.9
East Asian, South0
South Asian0
European, North16.38
European, South13.96
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_E8Z4 (BGC-823/DOX)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D6S104318,19
D7S8208,12
D8S117912,13
D12S39120,25
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313 (CCRID; PubMed=28851942; PubMed=29717028)
13,14 (PubMed=26116706)
D21S1127,28
FGA21 (CCRID; PubMed=26116706; PubMed=28851942)
21,24 (PubMed=29717028)
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=10374555
Guo-Qiang Zheng, Xu-Yi Liu, Fu-Sheng Han, Guang-Wei Xu;
Establishment and characterization of doxorubicin-resistant BGC-823/DOX of human gastric cancer cell line.
Zhonghua Wai Ke Za Zhi 35:262-264(1997)

PubMed=16344271; DOI=10.1093/carcin/bgi306
Na Li, Rui-Fang Guo, Wen-Mei Li, Jian-Min Shao, Shu-Ting Li, Kang Zhao, Xi-Shu Chen, Ning-Zhi Xu, Si-Qi Liu, You-Yong Lu;
A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide.
Carcinogenesis 27:1222-1231(2006)

PubMed=26116706; DOI=10.1096/fj.14-266718
Fang Ye, Chu-Guang Chen, Jian Qin, Jie Liu, Cong-Yi Zheng;
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w; PMCID=PMC5575032
Xiao-Cui Bian, Zhen-Li Yang, Hai-Liang Feng, Hao Sun, Yu-Qin Liu;
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29717028; DOI=10.1042/BSR20180277; PMCID=PMC6050193
Ye-Qian Zhang, Si-Te Yu, Zi-Zhen Zhang, Gang Zhao, Jia Xu;
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) CCTCC; GDC0151
ICLC; HTL98007 - Discontinued
Cell line databases/resources CLO; CLO_0001952
Cell_Model_Passport; SIDM01938
DepMap; ACH-001017
Anatomy/cell type resources BTO; BTO_0003878
Chemistry resources ChEMBL-Cells; CHEMBL3307635
ChEMBL-Targets; CHEMBL614526
PharmacoDB; BGC823_90_2019
PubChem_Cell_line; CVCL_3360
Encyclopedic resources Wikidata; Q54796238
Gene expression databases GEO; GSM828793
GEO; GSM843444
GEO; GSM1374404
Polymorphism and mutation databases Cosmic; 2267322
IARC_TP53; 24859
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30