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Cellosaurus BGC-823 (CVCL_3360)

[Text version]
Cell line name BGC-823
Synonyms BGC823
Accession CVCL_3360
Resource Identification Initiative To cite this cell line use: BGC-823 (RRID:CVCL_3360)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (CCRID; PubMed=26116706; PubMed=28851942). Originally thought to be a gastric adenocarcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00570.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis by 2D-DE.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000062, 3131C0001000700011). They were one of the sources for the STR profile of this entry.
Misspelling: BSG823; Note=Occasionally.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.77
East Asian, North2.9
East Asian, South0
South Asian0
European, North16.38
European, South13.96
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028

D19S43313 (CCRID; PubMed=28851942; PubMed=29717028)
13,14 (PubMed=26116706)
FGA21 (CCRID; PubMed=26116706; PubMed=28851942)
21,24 (PubMed=29717028)
Penta D8,15
Penta E7,17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=16344271; DOI=10.1093/carcin/bgi306
Li N., Guo R.-F., Li W.-M., Shao J.-M., Li S.-T., Zhao K., Chen X.-S., Xu N.-Z., Liu S.-Q., Lu Y.-Y.
A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide.
Carcinogenesis 27:1222-1231(2006)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w
Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29717028; DOI=10.1042/BSR20180277
Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J.
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections (Providers) CCTCC; GDC0151
ICLC; HTL98007 - Discontinued
Cell line databases/resources CLO; CLO_0001952
Cell_Model_Passport; SIDM01938
DepMap; ACH-001017
Anatomy/cell type resources BTO; BTO:0003878
Chemistry resources ChEMBL-Cells; CHEMBL3307635
ChEMBL-Targets; CHEMBL614526
PharmacoDB; BGC823_90_2019
PubChem_Cell_line; CVCL_3360
Encyclopedic resources Wikidata; Q54796238
Gene expression databases GEO; GSM828793
GEO; GSM843444
GEO; GSM1374404
Polymorphism and mutation databases Cosmic; 2267322
IARC_TP53; 24859
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number27