ID   BGC-823
AC   CVCL_3360
SY   BGC823
DR   BTO; BTO:0003878
DR   CLO; CLO_0001952
DR   Cell_Model_Passport; SIDM01938
DR   ChEMBL-Cells; CHEMBL3307635
DR   ChEMBL-Targets; CHEMBL614526
DR   Cosmic; 2267322
DR   DepMap; ACH-001017
DR   GEO; GSM828793
DR   GEO; GSM843444
DR   GEO; GSM1374404
DR   IARC_TP53; 24859
DR   ICLC; HTL98007
DR   PharmacoDB; BGC823_90_2019
DR   PubChem_Cell_line; CVCL_3360
DR   Wikidata; Q54796238
RX   PubMed=16344271;
RX   PubMed=26116706;
RX   PubMed=28851942;
RX   PubMed=29717028;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (CCRID; PubMed=26116706; PubMed=28851942). Originally thought to be a gastric adenocarcinoma.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00570.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Proteome analysis by 2D-DE.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=65.99%; Native American=0.77%; East Asian, North=2.9%; East Asian, South=0%; South Asian=0%; European, North=16.38%; European, South=13.96% (PubMed=30894373).
CC   Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000062, 3131C0001000700011). They were one of the sources for the STR profile of this entry.
CC   Misspelling: BSG823; Note=Occasionally.
CC   Discontinued: ICLC; HTL98007; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D12S391: 20,25
ST   D13S317: 12,13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13 (CCRID; PubMed=28851942; PubMed=29717028)
ST   D19S433: 13,14 (PubMed=26116706)
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D6S1043: 18,19
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 21 (CCRID; PubMed=26116706; PubMed=28851942)
ST   FGA: 21,24 (PubMed=29717028)
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 26
RX   PubMed=16344271; DOI=10.1093/carcin/bgi306;
RA   Li N., Guo R.-F., Li W.-M., Shao J.-M., Li S.-T., Zhao K., Chen X.-S.,
RA   Xu N.-Z., Liu S.-Q., Lu Y.-Y.;
RT   "A proteomic investigation into a human gastric cancer cell line
RT   BGC823 treated with diallyl trisulfide.";
RL   Carcinogenesis 27:1222-1231(2006).
RX   PubMed=26116706; DOI=10.1096/fj.14-266718;
RA   Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.;
RT   "Genetic profiling reveals an alarming rate of cross-contamination
RT   among human cell lines used in China.";
RL   FASEB J. 29:4268-4272(2015).
RX   PubMed=28851942; DOI=10.1038/s41598-017-09660-w;
RA   Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.;
RT   "A combination of species identification and STR profiling identifies
RT   cross-contaminated cells from 482 human tumor cell lines.";
RL   Sci. Rep. 7:9774-9774(2017).
RX   PubMed=29717028; DOI=10.1042/BSR20180277;
RA   Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J.;
RT   "Long non-coding RNA AK096174 promotes cell proliferation and invasion
RT   in gastric cancer by regulating WDR66 expression.";
RL   Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018).
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).