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Cellosaurus OCUB-F (CVCL_3352)

[Text version]
Cell line name OCUB-F
Synonyms OCUB-1F; OCUBF; OCUB-1 Floating
Accession CVCL_3352
Resource Identification Initiative To cite this cell line use: OCUB-F (RRID:CVCL_3352)
Comments Population: Japanese.
Microsatellite instability: Instable (MSI) (PubMed=15677628).
Omics: miRNA expression profiling.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 1748; CDH1; Simple; p.Val17fs*1 (c.49_163del115); Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala76Profs*70 (c.225delC); Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly244Ser (c.730G>A); ClinVar=VCV000376600; Zygosity=Unspecified (PubMed=16541312).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_L114 (OCUB-1)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): RCB=RCB0882


Run an STR similarity search on this cell line

Sawada T., Chung Y.-S., Nakata B., Kubo T., Kondo Y., Sogabe T., Onoda N., Ogawa Y., Yamada N., Sowa M.
Establishment and characterization of a human breast cancer cell line, OCUB-1.
Hum. Cell 7:138-144(1994)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H.C., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=23601657; DOI=10.1186/bcr3415
Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J.-J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A., Martens J.W.M.
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

Cell line collections (Providers) RCB; RCB0882
Cell line databases/resources CLO; CLO_0051610
cancercelllines; CVCL_3352
Biological sample resources BioSample; SAMN03472189
Encyclopedic resources Wikidata; Q54931815
Gene expression databases GEO; GSM217593
GEO; GSM219906
GEO; GSM421882
GEO; GSM459705
GEO; GSM1661986
Polymorphism and mutation databases Cosmic; 997934
Cosmic; 1046937
Cosmic; 1289404
IARC_TP53; 24358
Progenetix; CVCL_3352
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26