ID   OCUB-F
AC   CVCL_3352
SY   OCUB-1F; OCUBF; OCUB-1 Floating
DR   CLO; CLO_0051610
DR   BioSample; SAMN03472189
DR   Cosmic; 997934
DR   Cosmic; 1046937
DR   Cosmic; 1289404
DR   GEO; GSM217593
DR   GEO; GSM219906
DR   GEO; GSM421882
DR   GEO; GSM459705
DR   GEO; GSM1661986
DR   IARC_TP53; 24358
DR   Progenetix; CVCL_3352
DR   RCB; RCB0882
DR   Wikidata; Q54931815
RX   PubMed=7873497;
RX   PubMed=15677628;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=19593635;
RX   PubMed=23601657;
CC   Population: Japanese.
CC   Microsatellite instability: Instable (MSI) (PubMed=15677628).
CC   Sequence variation: Mutation; HGNC; 1748; CDH1; Simple; p.Val17fs*1 (c.49_163del115); Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala76Profs*70 (c.225delC); Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly244Ser (c.730G>A); ClinVar=VCV000376600; Zygosity=Unspecified (PubMed=16541312).
CC   Omics: miRNA expression profiling.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): RCB
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 8
ST   D16S539: 11
ST   D5S818: 10
ST   D7S820: 9,13
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 18,19
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_L114 ! OCUB-1
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 23
//
RX   PubMed=7873497;
RA   Sawada T., Chung Y.-S., Nakata B., Kubo T., Kondo Y., Sogabe T.,
RA   Onoda N., Ogawa Y., Yamada N., Sowa M.;
RT   "Establishment and characterization of a human breast cancer cell
RT   line, OCUB-1.";
RL   Hum. Cell 7:138-144(1994).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C.,
RA   Edwards P.A.W., Caldas C.;
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
RA   Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M.,
RA   van den Ouweland A., Merajver S.D., Ethier S.P., Schutte M.;
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
RX   PubMed=16541312; DOI=10.1007/s10549-006-9186-z;
RA   Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.;
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//
RX   PubMed=19593635; DOI=10.1007/s10549-009-0460-8;
RA   Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F.,
RA   Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J.,
RA   Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M.,
RA   Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M.,
RA   Dinjens W.N.M., Ethier S.P., Clevers H.C., Jochemsen A.G.,
RA   den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.;
RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//
RX   PubMed=23601657; DOI=10.1186/bcr3415;
RA   Riaz M., van Jaarsveld M.T.M., Hollestelle A.,
RA   Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J.,
RA   Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A.,
RA   Martens J.W.M.;
RT   "miRNA expression profiling of 51 human breast cancer cell lines
RT   reveals subtype and driver mutation-specific miRNAs.";
RL   Breast Cancer Res. 15:R33.1-R33.17(2013).
//