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Cellosaurus TMH-1 (CVCL_3219)

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Cell line name TMH-1
Accession CVCL_3219
Resource Identification Initiative To cite this cell line use: TMH-1 (RRID:CVCL_3219)
Comments Problematic cell line: Contaminated. Shown to be a IHH-4 derivative (PubMed=20143388). Originally thought to originate from a 79 year old female patient with a thyroid gland anaplastic carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00349.
Population: Japanese.
Derived from site: Metastatic; Left cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2348; CREBBP; Simple; p.Trp592Ter (c.1776G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:14281; CRLF2; Simple; p.Trp255Ter (c.765G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Arg1312Ter (c.3934C>T); ClinVar=VCV000545969; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Asp11Glu (c.33C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2960 (IHH-4)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1078

Markers:
AmelogeninX
CSF1PO12
D5S8189,13
D7S8209,10
D13S31710,13
D16S5399,11
TH019
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=11686581; DOI=10.1016/S0753-3322(01)00087-7
Morimasa Sekiguchi, Yasuko Shiroko, Tsutomu Arai, Tohru Kishino, Isamu Sugawara, Takashi Kusakabe, Tomoyuki Suzuki, Tomoyuki Yamashita, Takao Obara, K. Ito, Kenichiro Hasumi;
Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines.
Biomed. Pharmacother. 55:466-474(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB1078
JCRB; NIHS0267 - Discontinued
Cell line databases/resources cancercelllines; CVCL_3219
Cell_Model_Passport; SIDM00601
Biological sample resources BioSample; SAMN03151799
BioSample; SAMN03472499
Encyclopedic resources Wikidata; Q54972696
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28