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Cellosaurus IHH-4 (CVCL_2960)

[Text version]
Cell line name IHH-4
Synonyms IHH4
Accession CVCL_2960
Resource Identification Initiative To cite this cell line use: IHH-4 (RRID:CVCL_2960)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 42 hours (PubMed=11686581).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Left cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:2348; CREBBP; Simple; p.Trp592Ter (c.1776G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:14281; CRLF2; Simple; p.Trp255Ter (c.765G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Arg1312Ter (c.3934C>T); ClinVar=VCV000545969; Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Asp11Glu (c.33C>G); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=1240154; DepMap=ACH-001528).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.71
Native American0
East Asian, North73.08
East Asian, South21.44
South Asian0
European, North0.89
European, South2.88
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3219 (TMH-1)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1240154; DepMap=ACH-001528; JCRB=JCRB1079; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S8189,13
D7S8209,10
D8S117911,15
D13S31710,13
D16S5399,11
D18S5113,15
D21S1130,31
FGA23,24
Penta D9
Penta E10,12
TH019
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=11686581; DOI=10.1016/S0753-3322(01)00087-7
Morimasa Sekiguchi, Yasuko Shiroko, Tsutomu Arai, Tohru Kishino, Isamu Sugawara, Takashi Kusakabe, Tomoyuki Suzuki, Tomoyuki Yamashita, Takao Obara, K. Ito, Kenichiro Hasumi;
Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines.
Biomed. Pharmacother. 55:466-474(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1079
JCRB; NIHS0270 - Discontinued
JCRB; NIHS0270.1 - Discontinued
JCRB; NIHS0271.1 - Discontinued
Cell line databases/resources CLO; CLO_0037153
cancercelllines; CVCL_2960
Cell_Model_Passport; SIDM00600
Cosmic-CLP; 1240154
DepMap; ACH-001528
LINCS_LDP; LCL-1693
Biological sample resources BioSample; SAMN03481111
Chemistry resources GDSC; 1240154
PharmacoDB; IHH4_655_2019
Encyclopedic resources Wikidata; Q54897412
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827172
GEO; GSM1669931
Polymorphism and mutation databases Cosmic; 1995454
Cosmic; 2054088
Progenetix; CVCL_2960
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37