Cellosaurus cell line TMD5 (CVCL

Cellosaurus TMD5 (CVCL_3218)

[Text version]

Cell line name

TMD5

Synonyms

Tokyo Medical and Dental university 5

Accession

CVCL_3218

Resource Identification Initiative

To cite this cell line use: TMD5 (RRID:CVCL_3218)

Comments

Population: Japanese.
Doubling time: 50 hours (PubMed=10071078).
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Miscellaneous: STR profile from personal communication of Leo, Isabelle Rose.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072; PubMed=10071078; PubMed=35354797).

Disease

Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

19Y

Category

Cancer cell line

STR profile

Source(s): JCRB=IFO50516; Direct_author_submission

Markers:

Amelogenin	X,Y
CSF1PO	10,13
D1S1656	11,18.3
D2S441	10,12
D2S1338	17,19
D3S1358	15,17
D5S818	9,13
D7S820	10,11
D8S1179	10,14
D10S1248	12,16
D12S391	18,24
D13S317	8
D16S539	10,12
D18S51	14,15
D19S433	12,14.2
D21S11	30
D22S1045	11,17
DYS391	10
FGA	21,23
SE33	22,29.2
TH01	9
TPOX	8
vWA	17,18

Publications

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10071078; DOI=10.1016/S0145-2126(98)00172-6
Shuji Tohda, Chizuko Sakashita, Tetsuya Fukuda, Naomi Murakami, Nobuo Nara;
Establishment of a double Philadelphia chromosome-positive acute lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines and differentiation inducers on growth of the cells.
Leuk. Res. 23:255-261(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references

Cell line collections (Providers)

JCRB; IFO50516

Biological sample resources

BioSample; SAMN03472802

Encyclopedic resources

Wikidata; Q54972692

Gene expression databases

GEO; GSM5137748
GEO; GSM5137768

Proteomic databases

PRIDE; PXD023662

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number