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Cellosaurus TMD5 (CVCL_3218)

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Cell line name TMD5
Synonyms Tokyo Medical and Dental university 5
Accession CVCL_3218
Resource Identification Initiative To cite this cell line use: TMD5 (RRID:CVCL_3218)
Comments Population: Japanese.
Doubling time: 50 hours (PubMed=10071078).
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Miscellaneous: STR profile from personal communication of Leo, Isabelle Rose.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): JCRB=IFO50516; Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO10,13
D1S165611,18.3
D2S44110,12
D2S133817,19
D3S135815,17
D5S8189,13
D7S82010,11
D8S117910,14
D10S124812,16
D12S39118,24
D13S3178
D16S53910,12
D18S5114,15
D19S43312,14.2
D21S1130
D22S104511,17
DYS39110
FGA21,23
SE3322,29.2
TH019
TPOX8
vWA17,18

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Publications

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10071078; DOI=10.1016/S0145-2126(98)00172-6
Shuji Tohda, Chizuko Sakashita, Tetsuya Fukuda, Naomi Murakami, Nobuo Nara;
Establishment of a double Philadelphia chromosome-positive acute lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines and differentiation inducers on growth of the cells.
Leuk. Res. 23:255-261(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50516
Biological sample resources BioSample; SAMN03472802
Encyclopedic resources Wikidata; Q54972692
Gene expression databases GEO; GSM5137748
GEO; GSM5137768
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25