ID   TMD5
AC   CVCL_3218
SY   Tokyo Medical and Dental university 5
DR   BioSample; SAMN03472802
DR   GEO; GSM5137748
DR   GEO; GSM5137768
DR   JCRB; IFO50516
DR   PRIDE; PXD023662
DR   Wikidata; Q54972692
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=10071072;
RX   PubMed=10071078;
RX   PubMed=35124168;
RX   PubMed=35354797;
CC   Population: Japanese.
CC   Doubling time: 50 hours (PubMed=10071078).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072; PubMed=10071078; PubMed=35354797).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: STR profile from personal communication of Leo, Isabelle Rose.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): JCRB=IFO50516; Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 10,13
ST   D10S1248: 12,16
ST   D12S391: 18,24
ST   D13S317: 8
ST   D16S539: 10,12
ST   D18S51: 14,15
ST   D19S433: 12,14.2
ST   D1S1656: 11,18.3
ST   D21S11: 30
ST   D22S1045: 11,17
ST   D2S1338: 17,19
ST   D2S441: 10,12
ST   D3S1358: 15,17
ST   D5S818: 9,13
ST   D7S820: 10,11
ST   D8S1179: 10,14
ST   DYS391: 10
ST   FGA: 21,23
ST   SE33: 22,29.2
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10071078; DOI=10.1016/S0145-2126(98)00172-6;
RA   Tohda S., Sakashita C., Fukuda T., Murakami N., Nara N.;
RT   "Establishment of a double Philadelphia chromosome-positive acute
RT   lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines
RT   and differentiation inducers on growth of the cells.";
RL   Leuk. Res. 23:255-261(1999).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900;
RA   Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T.,
RA   Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E.,
RA   Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I.,
RA   Lehtio J., Vesterlund M., Jafari R.;
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//