ID   TMD5
AC   CVCL_3218
SY   Tokyo Medical and Dental university 5
DR   BioSample; SAMN03472802
DR   GEO; GSM5137748
DR   GEO; GSM5137768
DR   JCRB; IFO50516
DR   PRIDE; PXD023662
DR   Wikidata; Q54972692
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=10071072;
RX   PubMed=10071078;
RX   PubMed=35124168;
RX   PubMed=35354797;
CC   Population: Japanese.
CC   Doubling time: 50 hours (PubMed=10071078).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072; PubMed=10071078; PubMed=35354797).
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: STR profile from personal communication of Leo, Isabelle Rose.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): JCRB=IFO50516; Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 10,13
ST   D10S1248: 12,16
ST   D12S391: 18,24
ST   D13S317: 8
ST   D16S539: 10,12
ST   D18S51: 14,15
ST   D19S433: 12,14.2
ST   D1S1656: 11,18.3
ST   D21S11: 30
ST   D22S1045: 11,17
ST   D2S1338: 17,19
ST   D2S441: 10,12
ST   D3S1358: 15,17
ST   D5S818: 9,13
ST   D7S820: 10,11
ST   D8S1179: 10,14
ST   DYS391: 10
ST   FGA: 21,23
ST   SE33: 22,29.2
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai, Minori
RA   Kasai, Shin
RA   Akahane, Koshi
RA   Thu, Thao Nguyen
RA   Kagami, Keiko
RA   Komatsu, Chiaki
RA   Abe, Masako
RA   Watanabe, Atsushi
RA   Goi, Kumiko
RA   Miyake, Kunio
RA   Inaba, Toshiya
RA   Takita, Junko
RA   Goto, Hiroaki
RA   Minegishi, Masayoshi
RA   Iwamoto, Shotaro
RA   Sugita, Kanji
RA   Inukai, Takeshi
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10071078; DOI=10.1016/S0145-2126(98)00172-6;
RA   Tohda, Shuji
RA   Sakashita, Chizuko
RA   Fukuda, Tetsuya
RA   Murakami, Naomi
RA   Nara, Nobuo
RT   "Establishment of a double Philadelphia chromosome-positive acute
RT   lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines
RT   and differentiation inducers on growth of the cells.";
RL   Leuk. Res. 23:255-261(1999).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900;
RA   Leo, Isabelle Rose
RA   Aswad, Luay
RA   Stahl, Matthias
RA   Kunold, Elena
RA   Post, Frederik
RA   Erkers, Tom
RA   Struyf, Nona
RA   Mermelekas, Georgios
RA   Joshi, Rubin Narayan
RA   Gracia-Villacampa, Eva
RA   Ostling, Paivi
RA   Kallioniemi, Olli-Pekka
RA   Pokrovskaja Tamm, Katja
RA   Siavelis, Ioannis
RA   Lehtio, Janne
RA   Vesterlund, Mattias
RA   Jafari, Rozbeh
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//