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Cellosaurus NC-37 (CVCL_3042)

[Text version]
Cell line name NC-37
Synonyms NC 37; NC37; Nc37
Accession CVCL_3042
Resource Identification Initiative To cite this cell line use: NC-37 (RRID:CVCL_3042)
Comments Problematic cell line: Contaminated. Shown to be a Raji derivative (PubMed=20143388). Originally thought to originate from the peripheral blood of a human donor not suffering from a disease.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00330.
Population: African; Nigerian.
Doubling time: ~20 hours (HIVReagentProgram=ARP-9936).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: SNP array analysis.
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-214; JCRB=IFO50039; TKG=TKG 0232

D13S31713 (JCRB=IFO50039; TKG=TKG 0232)
13,14 (ATCC=CCL-214)
Penta D3.2,9
Penta E5,13
vWA16 (ATCC=CCL-214)
16,19 (JCRB=IFO50039; TKG=TKG 0232)

Run an STR similarity search on this cell line
Web pages https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm

PubMed=4321017; DOI=10.1002/ijc.2910060315
Durr F.E., Monroe J.H., Schmitter R., Traul K.A., Hirshaut Y.
Studies on the infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells.
Int. J. Cancer 6:436-449(1970)

Minowada J., Nonoyama M., Moore G.E., Rauch A.M., Pagano J.S.
The presence of the Epstein-Barr viral genome in human lymphoblastoid B-cell lines and its absence in a myeloma cell line.
Cancer Res. 34:1898-1903(1974)

PubMed=165156; DOI=10.1002/ijc.2910150217
Nilsson K., Ponten J.
Classification and biological nature of established human hematopoietic cell lines.
Int. J. Cancer 15:321-341(1975)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Adams A., Strander H., Cantell K.
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=375235; DOI=10.1073/pnas.76.3.1288
Sherwin S.A., Sliski A.H., Todaro G.J.
Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.
Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979)

PubMed=6401685; DOI=10.1007/BF02617989
Halton D.M., Peterson W.D. Jr., Hukku B.
Cell culture quality control by rapid isoenzymatic characterization.
In Vitro 19:16-24(1983)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

Cell line collections (Providers) ATCC; CCL-214
ECACC; 89111414 - Discontinued
HIVReagentProgram; ARP-9936
JCRB; IFO50039
KCLB; 10214 - Discontinued
NCBI_Iran; C501
RCB; RCB3008
TKG; TKG 0232
Cell line databases/resources CLO; CLO_0007952
CLDB; cl3648
CLDB; cl3649
cancercelllines; CVCL_3042
Cell_Model_Passport; SIDM01207
IGRhCellID; NC37
Anatomy/cell type resources BTO; BTO:0005495
Biological sample resources BioSample; SAMN03151899
BioSample; SAMN03471475
Chemistry resources ChEMBL-Cells; CHEMBL3307322
ChEMBL-Targets; CHEMBL614189
PubChem_Cell_line; CVCL_3042
Encyclopedic resources Wikidata; Q54907589
Experimental variables resources EFO; EFO_0002247
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Cosmic; 687848
Progenetix; CVCL_3042
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number33