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Cellosaurus NC-37 (CVCL_3042)

[Text version]
Cell line name NC-37
Synonyms NC 37; NC37; Nc37
Accession CVCL_3042
Resource Identification Initiative To cite this cell line use: NC-37 (RRID:CVCL_3042)
Comments Problematic cell line: Contaminated. Shown to be a Raji derivative (PubMed=20143388). Originally thought to originate from the peripheral blood of a human donor not suffering from a disease.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00330.
Population: African; Nigerian.
Doubling time: ~20 hours (BEI_Resources=ARP-9936).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Children:
CVCL_S547 (NC-37/DC-SIGN)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-214; JCRB=IFO50039; TKG=TKG 0232

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822
D3S135816
D5S81810,13
D7S82010
D8S117914,15
D13S31713 (JCRB=IFO50039; TKG=TKG 0232)
13,14 (ATCC=CCL-214)
D16S5398,11
D18S5115,17
D19S43314,14.2
D21S1128,31
FGA19,27
Penta D3.2,9
Penta E5,13
TH016,7
TPOX8,13
vWA16 (ATCC=CCL-214)
16,19 (JCRB=IFO50039; TKG=TKG 0232)

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; JCRB; -; https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm
Publications

PubMed=4321017; DOI=10.1002/ijc.2910060315
Frederick E. Durr, James H. Monroe, Rene Schmitter, Karl A. Traul, Yashar Hirshaut;
Studies on the infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells.
Int. J. Cancer 6:436-449(1970)

PubMed=4366935
Jun Minowada, Meihan Nonoyama, George Eugene Moore, Alan M. Rauch, Joseph S. Pagano;
The presence of the Epstein-Barr viral genome in human lymphoblastoid B-cell lines and its absence in a myeloma cell line.
Cancer Res. 34:1898-1903(1974)

PubMed=165156; DOI=10.1002/ijc.2910150217
Kenneth Nilsson, Jan Ponten;
Classification and biological nature of established human hematopoietic cell lines.
Int. J. Cancer 15:321-341(1975)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Alice Adams, Hans Strander, Kari Cantell;
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=375235; DOI=10.1073/pnas.76.3.1288; PMCID=PMC383236
Stephen A. Sherwin, Ann H. Sliski, George J. Todaro;
Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.
Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979)

PubMed=6401685; DOI=10.1007/BF02617989
David Michael Halton, Ward Davis Peterson Jr., Bharati Hukku;
Cell culture quality control by rapid isoenzymatic characterization.
In Vitro 19:16-24(1983)

PubMed=6500159; DOI=10.1159/000163283
Merrill Eric Gershwin, Daniel Lentz, Robert B. Owens;
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783
Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano ...Show all 15 authors... , Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara; Show fewer authors
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

Cross-references
Cell line collections (Providers) ATCC; CCL-214
BEI_Resources; ARP-9936
ECACC; 89111414 - Discontinued
JCRB; IFO50039
KCLB; 10214 - Discontinued
NCBI_Iran; C501
NCI-DTP; NC-37
RCB; RCB3008
TKG; TKG 0232
Cell line databases/resources CLO; CLO_0007952
CLDB; cl3648
CLDB; cl3649
cancercelllines; CVCL_3042
Cell_Model_Passport; SIDM01207
IGRhCellID; NC37
LINCS_LDP; LCL-2057
Anatomy/cell type resources BTO; BTO_0005495
Biological sample resources BioSample; SAMN03151899
BioSample; SAMN03471475
Chemistry resources ChEMBL-Cells; CHEMBL3307322
ChEMBL-Targets; CHEMBL614189
PubChem_Cell_line; CVCL_3042
Encyclopedic resources Wikidata; Q54907589
Experimental variables resources EFO; EFO_0002247
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Cosmic; 687848
Progenetix; CVCL_3042
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36