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Cellosaurus KP-3L (CVCL_3006)

[Text version]
Cell line name KP-3L
Synonyms KP-3-L; KP3L; KP-3Ls
Accession CVCL_3006
Resource Identification Initiative To cite this cell line use: KP-3L (RRID:CVCL_3006)
Comments Population: Japanese.
Characteristics: Established from parent cell line through a nude mice tumor.
Doubling time: ~34 hours (Note=Lot 03222016), ~2 days (Note=Lot 06292006) (JCRB=JCRB0178.1).
Omics: Metabolome analysis.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (PubMed=21607521).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Glu538Ter (c.1612G>T); ClinVar=VCV000581974; Zygosity=Homozygous (PubMed=18380791).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
Disease Pancreatic adenosquamous carcinoma (NCIt: C5721)
Squamous cell carcinoma of pancreas (ORDO: Orphanet_424039)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3005 (KP-3)
Children:
CVCL_4Y22 (KP-3L-Luc#5)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0178.1; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D3S135816,17
D5S81813
D7S82010,12 (JCRB=JCRB0178.1)
12 (PubMed=25877200)
D8S117913,14
D13S3179,11
D16S5399,13
D18S5117
D21S1130,32,33
FGA23
Penta D12,13
Penta E15,17
TH016,9.3 (PubMed=25877200)
6,10 (JCRB=JCRB0178.1)
TPOX9,11 (JCRB=JCRB0178.1)
11 (PubMed=25877200)
vWA17,18 (JCRB=JCRB0178.1)
18 (PubMed=25877200)

Run an STR similarity search on this cell line
Publications

PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x; PMCID=PMC5917979
Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.
Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.
Jpn. J. Cancer Res. 81:987-993(1990)

PubMed=21607521; DOI=10.3892/or.1.6.1223
Iguchi H., Morita R., Yasuda D., Takayanagi R., Ikeda Y., Takada Y., Shimazoe T., Nawata H., Kono A.
Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
Oncol. Rep. 1:1223-1227(1994)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928
Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616
Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R.L., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

Cross-references
Cell line collections (Providers) JCRB; JCRB0178.1
JCRB; NIHS0275.1 - Discontinued
Cell line databases/resources CLO; CLO_0037109
cancercelllines; CVCL_3006
Cell_Model_Passport; SIDM00559
CGH-DB; 177-1
CGH-DB; 9372-4
LINCS_LDP; LCL-1724
Biological sample resources BioSample; SAMN03472946
Encyclopedic resources Wikidata; Q54900368
Polymorphism and mutation databases Cosmic; 918049
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24