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Cellosaurus KAI3 (CVCL_2969)

[Text version]
Cell line name KAI3
Accession CVCL_2969
Resource Identification Initiative To cite this cell line use: KAI3 (RRID:CVCL_2969)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 3.5 days (Note=Lot 03082007), ~76 hours (Note=Lot 07312015) (JCRB=IFO50518).
Karyotypic information: 46,XY,add(6)(p23),der(6)add(6)(p23)add(6)(q21) (PubMed=10193407).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Donor information: Established from a donor with severe hypersensitivity to mosquito bite (HMB) (PubMed=10193407).
Misspelling: KA13; Cosmic=2390216.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Natural killer cell; CL=CL_0000623.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 13Y
Category Transformed cell line
STR profile Source(s): JCRB=IFO50518

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S82010,12
D13S3178,11
D16S5399,10
TH018,9
TPOX8,11
vWA17,18

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Publications

PubMed=10193407; DOI=10.1046/j.1365-2249.1999.00836.x; PMCID=PMC1905265
Ikuya Tsuge, Tsuneo Morishima, M. Morita, H. Kimura, Kiyotaka Kuzushima, H. Matsuoka;
Characterization of Epstein-Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy establishment of an IL-2-dependent NK-like cell line.
Clin. Exp. Immunol. 115:385-392(1999)

PubMed=19194464; DOI=10.1038/leu.2009.3
Javeed Iqbal, Can Kucuk, Ronald J. Deleeuw, Gopesh Srivastava, Wayne Tam, Hui-Min Geng, David L. Klinkebiel, Judith K. Christman, Kavita N. Patel, K. Cao, L. Shen ...Show all 18 authors... , Karen Dybkaer, Ivy F.L. Tsui, Hesham H. Ali, N. Shimizu, Wing Yan Au, Wan L. Lam, Wing-Chung Chan; Show fewer authors
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Javeed Iqbal, Dennis D. Weisenburger, Aparajita Chowdhury, Ming-Ying Tsai, Gopesh Srivastava, Timothy Charles Greiner, Can Kucuk, Karen E. Deffenbacher, Julie Marie Vose, L. Smith, Wing Yan Au ...Show all 22 authors... , Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Young-Hyeh Ko, Ivy Sng, X. Liu, Thomas P. Loughran Jr., James Olen Armitage, Wing-Chung Chan; Show fewer authors
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911
Can Kucuk, Bei Jiang, Xiao-Zhou Hu, Wen-Yan Zhang, John K.C. Chan, Wen-Ming Xiao, Nathan Lack, Can Alkan, John C. Williams, Kendra N. Avery, Pynar Kavak ...Show all 28 authors... , Anna Scuto, Emel Sen, Philippe Gaulard, Louis Michael Staudt, Javeed Iqbal, Wei-Wei Zhang, Adam Cornish, Qiang Gong, Qun-Pei Yang, Hong Sun, Francesco Annibale d'Amore, Sirpa Leppa, Wei-Ping Liu, Kai Fu, Laurence de Leval, Timothy W. McKeithan, Wing-Chung Chan; Show fewer authors
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783
Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano ...Show all 15 authors... , Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara; Show fewer authors
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=36094314; DOI=10.1128/JVI.00739-22; PMCID=PMC9517713
Wei-Yue Ding, Chong Wang, Yohei Narita, Hong-Bo Wang, Merrin Man Long Leong, Alvin Huang, Yi-Fei Liao, Xue-Feng Liu, Yusuke Okuno, Hiroshi Kimura, Benjamin Elison Gewurz ...Show all 15 authors... , Ming-Xian Teng, Shui-Lin Jin, Yoshitaka Sato, Bo Zhao; Show fewer authors
The Epstein-Barr virus enhancer interaction landscapes in virus-associated cancer cell lines.
J. Virol. 96:e00739.22.1-e00739.22.11(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50518
Biological sample resources BioSample; SAMN03472803
Encyclopedic resources Wikidata; Q54899458
Gene expression databases GEO; GSM471999
Polymorphism and mutation databases Cosmic; 1542077
Cosmic; 2390216
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21