ID   KAI3
AC   CVCL_2969
DR   BioSample; SAMN03472803
DR   Cosmic; 1542077
DR   Cosmic; 2390216
DR   GEO; GSM471999
DR   JCRB; IFO50518
DR   Wikidata; Q54899458
RX   PubMed=10193407;
RX   PubMed=19194464;
RX   PubMed=21052088;
RX   PubMed=25586472;
RX   PubMed=29892436;
RX   PubMed=36094314;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Doubling time: 3.5 days (Note=Lot 03082007), ~76 hours (Note=Lot 07312015) (JCRB=IFO50518).
CC   Karyotypic information: 46,XY,add(6)(p23),der(6)add(6)(p23)add(6)(q21) (PubMed=10193407).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Donor information: Established from a donor with severe hypersensitivity to mosquito bite (HMB) (PubMed=10193407).
CC   Misspelling: KA13; Cosmic=2390216.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: Natural killer cell; CL=CL_0000623.
ST   Source(s): JCRB=IFO50518
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 9,10
ST   D5S818: 11
ST   D7S820: 10,12
ST   TH01: 8,9
ST   TPOX: 8,11
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   13Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 21
//
RX   PubMed=10193407; DOI=10.1046/j.1365-2249.1999.00836.x; PMCID=PMC1905265;
RA   Tsuge I., Morishima T., Morita M., Kimura H., Kuzushima K.,
RA   Matsuoka H.;
RT   "Characterization of Epstein-Barr virus (EBV)-infected natural killer
RT   (NK) cell proliferation in patients with severe mosquito allergy;
RT   establishment of an IL-2-dependent NK-like cell line.";
RL   Clin. Exp. Immunol. 115:385-392(1999).
//
RX   PubMed=19194464; DOI=10.1038/leu.2009.3;
RA   Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H.-M.,
RA   Klinkebiel D.L., Christman J.K., Patel K.N., Cao K., Shen L., Dybkaer K.,
RA   Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.;
RT   "Genomic analyses reveal global functional alterations that promote
RT   tumor growth and novel tumor suppressor genes in natural killer-cell
RT   malignancies.";
RL   Leukemia 23:1139-1151(2009).
//
RX   PubMed=21052088; DOI=10.1038/leu.2010.255;
RA   Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G.,
RA   Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y.,
RA   Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H.,
RA   Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.;
RT   "Natural killer cell lymphoma shares strikingly similar molecular
RT   features with a group of non-hepatosplenic gammadelta T-cell lymphoma
RT   and is highly sensitive to a novel aurora kinase A inhibitor in
RT   vitro.";
RG   International Peripheral T-cell Lymphoma Project;
RL   Leukemia 25:348-358(2011).
//
RX   PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911;
RA   Kucuk C., Jiang B., Hu X.-Z., Zhang W.-Y., Chan J.K.C., Xiao W.-M.,
RA   Lack N., Alkan C., Williams J.C., Avery K.N., Kavak P., Scuto A.,
RA   Sen E., Gaulard P., Staudt L.M., Iqbal J., Zhang W.-W., Cornish A.,
RA   Gong Q., Yang Q.-P., Sun H., d'Amore F.A., Leppa S., Liu W.-P., Fu K.,
RA   de Leval L., McKeithan T.W., Chan W.-C.;
RT   "Activating mutations of STAT5B and STAT3 in lymphomas derived from
RT   gammadelta-T or NK cells.";
RL   Nat. Commun. 6:6025.1-6025.12(2015).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=36094314; DOI=10.1128/JVI.00739-22; PMCID=PMC9517713;
RA   Ding W.-Y., Wang C., Narita Y., Wang H.-B., Leong M.M.L., Huang A.,
RA   Liao Y.-F., Liu X.-F., Okuno Y., Kimura H., Gewurz B.E., Teng M.-X.,
RA   Jin S.-L., Sato Y., Zhao B.;
RT   "The Epstein-Barr virus enhancer interaction landscapes in
RT   virus-associated cancer cell lines.";
RL   J. Virol. 96:e00739.22.1-e00739.22.11(2022).
//