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Cellosaurus K562 AZQR (CVCL_2967)

[Text version]
Cell line name K562 AZQR
Synonyms K562-AZQR; K562AZQR; AZQR
Accession CVCL_2967
Resource Identification Initiative To cite this cell line use: K562 AZQR (RRID:CVCL_2967)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90185; Diaziquone (AZQ).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117912
D18S5115,17
D21S1129,30
FGA21,24
TH019.3
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=7646550; DOI=10.1016/0006-2952(95)00155-S
Ward T.H., Haran M.S., Whittaker D., Watson A.J., Howard T.D., Butler J.
Cross-resistance studies on two K562 sublines resistant to diaziridinylbenzoquinones.
Biochem. Pharmacol. 50:459-464(1995)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

Cross-references
Cell line collections (Providers) CancerTools; 153252
ECACC; 93112521 - Discontinued
KCB; KCB 2015019YJ
Ximbio; 153252
Cell line databases/resources CCRID; 5301HUM-KCB15019YJ
Encyclopedic resources Wikidata; Q54899291
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28