ID   K562 AZQR
AC   CVCL_2967
SY   K562-AZQR; K562AZQR; AZQR
DR   CancerTools; 153252
DR   CCRID; 5301HUM-KCB15019YJ
DR   ECACC; 93112521
DR   KCB; KCB 2015019YJ
DR   Wikidata; Q54899291
DR   Ximbio; 153252
RX   PubMed=7646550;
RX   PubMed=11416159;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_90185; Diaziquone (AZQ).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Discontinued: ECACC; 93112521; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=11416159
ST   Amelogenin: X
ST   D18S51: 15,17
ST   D21S11: 29,30
ST   D8S1179: 12
ST   FGA: 21,24
ST   TH01: 9.3
ST   vWA: 16
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 28
//
RX   PubMed=7646550; DOI=10.1016/0006-2952(95)00155-S;
RA   Ward, Timothy H.
RA   Haran, M. Sally
RA   Whittaker, Dee
RA   Watson, Amanda Jean
RA   Howard, Tina D.
RA   Butler, John
RT   "Cross-resistance studies on two K562 sublines resistant to
RT   diaziridinylbenzoquinones.";
RL   Biochem. Pharmacol. 50:459-464(1995).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//