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Cellosaurus U-373MG Uppsala (CVCL_2818)

[Text version]
Cell line name U-373MG Uppsala
Synonyms U-373 MG Uppsala; U-373 MG (Uppsala); U-373MG; U373 MG; U-373-MG; U-373 MG; U373-MG; U373MG; U373; 373 MG; 373MG
Accession CVCL_2818
Resource Identification Initiative To cite this cell line use: U-373MG Uppsala (RRID:CVCL_2818)
Comments Caution: This is the original U-373MG cell line established in 1973 at the University of Uppsala. The cell line distributed by most cell collections is a different cell line.
Derived from site: In situ; Brain, temporal lobe; UBERON=UBERON_0001871.
Sequence variations
  • Mutation; HGNC; HGNC:5382; IDH1; None_reported; -; Zygosity=- (PubMed=19435942).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Ile135_Ala137delinsThr (c.404_409delTATGTG); Zygosity=Unspecified (PubMed=10560660).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): ECACC=08061901; PubMed=27582061

Markers:
AmelogeninX
CSF1PO11,12
D2S133817,25
D3S135817
D5S81812
D7S8208,12 (PubMed=27582061)
8.2,12 (ECACC=08061901)
D8S117913,16
D13S3178
D16S53912,13
D18S5114,22
D19S43313,14
D21S1128,32.2
FGA20
Penta D9,13
Penta E11,13
TH017,9.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=4134536; DOI=10.1002/ijc.2910120215
Bengt Westermark;
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Int. J. Cancer 12:438-451(1973)

PubMed=4359449; DOI=10.1111/j.1699-0463.1973.tb03573.x
Bengt Westermark, Jan Ponten, Rune Hugosson;
Determinants for the establishment of permanent tissue culture lines from human gliomas.
Acta Pathol. Microbiol. Scand. A. 81:791-805(1973)

PubMed=4369403; DOI=10.1002/1097-0142(197408)34:2<274::AID-CNCR2820340209>3.0.CO;2-4
Torsten Wahlstrom, Ewert Linder, Eero Saksela, Bengt Westermark;
Tumor-specific membrane antigens in established cell lines from gliomas.
Cancer 34:274-279(1974)

DOI=10.1007/978-1-4757-1647-4_7
Jan Ponten;
Neoplastic human glia cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.175-206; Springer; New York; USA (1975)

PubMed=3675803
Sandra H. Bigner, Rolf Bjerkvig, Ole Didrik Laerum, Laurence H. Muhlbaier, Darell Doty Bigner;
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Anal. Quant. Cytol. Histol. 9:435-444(1987)

PubMed=2454731
Monica Nister, Towia Aron Libermann, Christer Betsholtz, Monica Pettersson, Lena Claesson-Welsh, Carl-Henrik Heldin, Joseph Schlessinger, Bengt Westermark;
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Cancer Res. 48:3910-3918(1988)

PubMed=1847665
Erik Bongcam-Rudloff, Monica Nister, Christer Betsholtz, Jia-Lun Wang, Goran Stenman, Kay Huebner, Carlo Maria Croce, Bengt Westermark;
Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
Cancer Res. 51:1553-1560(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Monica Nister, Bengt Westermark;
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10560660; DOI=10.1097/00005072-199911000-00007
Esther E. Schmidt, Koichi Ichimura, Helena M. Goike, Ahmad Moshref, Lu Liu, Vincent Peter Collins;
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

PubMed=19435942; DOI=10.1215/15228517-2009-025; PMCID=PMC2743214
Koichi Ichimura, Danita M. Pearson, Sylvia Kocialkowski, L. Magnus Backlund, Raymond Chan, David T.W. Jones, Vincent Peter Collins;
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853
Marie Allen, Mia Bjerke, Hanna Edlund, Sven Nelander, Bengt Westermark;
Origin of the U87MG glioma cell line: good news and bad news.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016)

Cross-references
Cell line collections (Providers) ECACC; 08061901
Biological sample resources BioSample; SAMN03471311
Encyclopedic resources Wikidata; Q54973576
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21