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Cellosaurus U-373MG Uppsala (CVCL_2818)

[Text version]
Cell line name U-373MG Uppsala
Synonyms U-373 MG Uppsala; U-373 MG (Uppsala); U-373MG; U373 MG; U-373-MG; U-373 MG; U373-MG; U373MG; U373; 373 MG; 373MG
Accession CVCL_2818
Resource Identification Initiative To cite this cell line use: U-373MG Uppsala (RRID:CVCL_2818)
Comments Caution: This is the original U-373MG cell line established in 1973 at the University of Uppsala. The cell line distributed by most cell collections is a different cell line.
Derived from site: In situ; Brain, temporal lobe; UBERON=UBERON_0001871.
Sequence variations
  • Mutation; HGNC; 5382; IDH1; None_reported; -; Zygosity=- (PubMed=19435942).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Ile135_Ala137delinsThr (c.404_409delTATGTG); Zygosity=Unspecified (PubMed=10560660).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=27582061

Markers:
AmelogeninX
CSF1PO11,12
D2S133817,25
D3S135817
D5S81812
D7S8208,12 (PubMed=27582061)
8.2,12 (ECACC)
D8S117913,16
D13S3178
D16S53912,13
D18S5114,22
D19S43313,14
D21S1128,32.2
FGA20
Penta D9,13
Penta E11,13
TH017,9.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=4134536; DOI=10.1002/ijc.2910120215
Westermark B.
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Int. J. Cancer 12:438-451(1973)

PubMed=4359449; DOI=10.1111/j.1699-0463.1973.tb03573.x
Westermark B., Ponten J., Hugosson R.
Determinants for the establishment of permanent tissue culture lines from human gliomas.
Acta Pathol. Microbiol. Scand. A. 81:791-805(1973)

PubMed=4369403; DOI=10.1002/1097-0142(197408)34:2<274::AID-CNCR2820340209>3.0.CO;2-4
Wahlstrom T., Linder E., Saksela E., Westermark B.
Tumor-specific membrane antigens in established cell lines from gliomas.
Cancer 34:274-279(1974)

DOI=10.1007/978-1-4757-1647-4_7
Ponten J.
Neoplastic human glia cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.175-206; Springer; New York (1975)

PubMed=3675803
Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Anal. Quant. Cytol. Histol. 9:435-444(1987)

PubMed=2454731
Nister M., Libermann T.A., Betsholtz C., Pettersson M., Claesson-Welsh L., Heldin C.-H., Schlessinger J., Westermark B.
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Cancer Res. 48:3910-3918(1988)

PubMed=1847665
Bongcam-Rudloff E., Nister M., Betsholtz C., Wang J.-L., Stenman G., Huebner K., Croce C.M., Westermark B.
Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
Cancer Res. 51:1553-1560(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

DOI=10.1007/0-306-46861-1_11
Ali-Osman F.
Brain tumors.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999)

PubMed=10560660; DOI=10.1097/00005072-199911000-00007
Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L., Collins V.P.
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

PubMed=19435942; DOI=10.1215/15228517-2009-025
Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R., Jones D.T.W., Collins V.P.
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853
Allen M., Bjerke M., Edlund H., Nelander S., Westermark B.
Origin of the U87MG glioma cell line: good news and bad news.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016)

Cross-references
Cell line collections (Providers) ECACC; 08061901
Biological sample resources BioSample; SAMN03471311
Encyclopedic resources Wikidata; Q54973576
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number19