ID   U-373MG Uppsala
AC   CVCL_2818
SY   U-373 MG Uppsala; U-373 MG (Uppsala); U-373MG; U373 MG; U-373-MG; U-373 MG; U373-MG; U373MG; U373; 373 MG; 373MG
DR   BioSample; SAMN03471311
DR   ECACC; 08061901
DR   Wikidata; Q54973576
RX   DOI=10.1007/0-306-46861-1_11;
RX   DOI=10.1007/978-1-4757-1647-4_7;
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RX   PubMed=1847665;
RX   PubMed=2454731;
RX   PubMed=3675803;
RX   PubMed=4134536;
RX   PubMed=4359449;
RX   PubMed=4369403;
RX   PubMed=10560660;
RX   PubMed=19435942;
RX   PubMed=27582061;
CC   Sequence variation: Mutation; HGNC; 5382; IDH1; None_reported; -; Zygosity=- (PubMed=19435942).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Ile135_Ala137delinsThr (c.404_409delTATGTG); Zygosity=Unspecified (PubMed=10560660).
CC   Caution: This is the original U-373MG cell line established in 1973 at the University of Uppsala. The cell line distributed by most cell collections is a different cell line.
CC   Derived from site: In situ; Brain, temporal lobe; UBERON=UBERON_0001871.
ST   Source(s): ECACC; PubMed=27582061
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8
ST   D16S539: 12,13
ST   D18S51: 14,22
ST   D19S433: 13,14
ST   D21S11: 28,32.2
ST   D2S1338: 17,25
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 8,12 (PubMed=27582061)
ST   D7S820: 8.2,12 (ECACC)
ST   D8S1179: 13,16
ST   FGA: 20
ST   Penta D: 9,13
ST   Penta E: 11,13
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 19
//
RX   DOI=10.1007/0-306-46861-1_11;
RA   Ali-Osman F.;
RT   "Brain tumors.";
RL   (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999).
//
RX   DOI=10.1007/978-1-4757-1647-4_7;
RA   Ponten J.;
RT   "Neoplastic human glia cells in culture.";
RL   (In) Human tumor cells in vitro; Fogh J. (eds.); pp.175-206; Springer; New York (1975).
//
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RA   Nister M., Westermark B.;
RT   "Human glioma cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994).
//
RX   PubMed=1847665;
RA   Bongcam-Rudloff E., Nister M., Betsholtz C., Wang J.-L., Stenman G.,
RA   Huebner K., Croce C.M., Westermark B.;
RT   "Human glial fibrillary acidic protein: complementary DNA cloning,
RT   chromosome localization, and messenger RNA expression in human glioma
RT   cell lines of various phenotypes.";
RL   Cancer Res. 51:1553-1560(1991).
//
RX   PubMed=2454731;
RA   Nister M., Libermann T.A., Betsholtz C., Pettersson M.,
RA   Claesson-Welsh L., Heldin C.-H., Schlessinger J., Westermark B.;
RT   "Expression of messenger RNAs for platelet-derived growth factor and
RT   transforming growth factor-alpha and their receptors in human
RT   malignant glioma cell lines.";
RL   Cancer Res. 48:3910-3918(1988).
//
RX   PubMed=3675803;
RA   Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.;
RT   "DNA content and chromosomes in permanent cultured cell lines derived
RT   from malignant human gliomas.";
RL   Anal. Quant. Cytol. Histol. 9:435-444(1987).
//
RX   PubMed=4134536; DOI=10.1002/ijc.2910120215;
RA   Westermark B.;
RT   "The deficient density-dependent growth control of human malignant
RT   glioma cells and virus-transformed glia-like cells in culture.";
RL   Int. J. Cancer 12:438-451(1973).
//
RX   PubMed=4359449; DOI=10.1111/j.1699-0463.1973.tb03573.x;
RA   Westermark B., Ponten J., Hugosson R.;
RT   "Determinants for the establishment of permanent tissue culture lines
RT   from human gliomas.";
RL   Acta Pathol. Microbiol. Scand. A. 81:791-805(1973).
//
RX   PubMed=4369403; DOI=10.1002/1097-0142(197408)34:2<274::AID-CNCR2820340209>3.0.CO;2-4;
RA   Wahlstrom T., Linder E., Saksela E., Westermark B.;
RT   "Tumor-specific membrane antigens in established cell lines from
RT   gliomas.";
RL   Cancer 34:274-279(1974).
//
RX   PubMed=10560660; DOI=10.1097/00005072-199911000-00007;
RA   Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L.,
RA   Collins V.P.;
RT   "Mutational profile of the PTEN gene in primary human astrocytic
RT   tumors and cultivated xenografts.";
RL   J. Neuropathol. Exp. Neurol. 58:1170-1183(1999).
//
RX   PubMed=19435942; DOI=10.1215/15228517-2009-025;
RA   Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R.,
RA   Jones D.T.W., Collins V.P.;
RT   "IDH1 mutations are present in the majority of common adult gliomas
RT   but rare in primary glioblastomas.";
RL   Neuro-oncol. 11:341-347(2009).
//
RX   PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853;
RA   Allen M., Bjerke M., Edlund H., Nelander S., Westermark B.;
RT   "Origin of the U87MG glioma cell line: good news and bad news.";
RL   Sci. Transl. Med. 8:354re3.1-354re3.4(2016).
//