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Cellosaurus KOSC-3 (CVCL_2789)

[Text version]
Cell line name KOSC-3
Synonyms KOSC3; Kobe university Oral Squamous Cell culture-3
Accession CVCL_2789
Resource Identification Initiative To cite this cell line use: KOSC-3 (RRID:CVCL_2789)
Comments Problematic cell line: Contaminated. Shown to be a Ca9-22 derivative (PubMed=20143388). Originally thought to originate from a 72 year old female patient with a lower-gingiva squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00324.
Population: Japanese.
Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=8314315).
Disease Gingival squamous cell carcinoma (NCIt: C129857)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1102 (Ca9-22)
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): JCRB


Run an STR similarity search on this cell line
Web pages https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm

PubMed=8314315; DOI=10.1002/ijc.2910560226
Inagaki T., Matsuwari S., Takahashi R., Shimada K.-k., Fujie K., Maeda S.
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) JCRB; JCRB0127
JCRB; NIHS0166 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2789
Anatomy/cell type resources BTO; BTO:0005969
Biological sample resources BioSample; SAMN03151615
BioSample; SAMN03470802
Encyclopedic resources Wikidata; Q54900342
Polymorphism and mutation databases Cosmic; 753571
Cosmic; 1120706
IARC_TP53; 2969
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26