Cellosaurus cell line KOSC-3 (CVCL

Cellosaurus KOSC-3 (CVCL_2789)

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Cell line name

KOSC-3

Synonyms

KOSC3; Kobe university Oral Squamous Cell culture-3

Accession

CVCL_2789

Resource Identification Initiative

To cite this cell line use: KOSC-3 (RRID:CVCL_2789)

Comments

Problematic cell line: Contaminated. Shown to be a Ca9-22 derivative (PubMed=20143388). Originally thought to originate from a 72 year old female patient with a lower-gingiva squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00324.
Population: Japanese.
Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=8314315).

Disease

Gingival squamous cell carcinoma (NCIt: C129857)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1102 (Ca9-22)

Sex of cell

Male

Age at sampling

43Y

Category

Cancer cell line

STR profile

Source(s): JCRB=JCRB0127

Markers:

Amelogenin	X,Y
CSF1PO	12
D5S818	12
D7S820	11,13
D13S317	11
D16S539	9,10
TH01	6
TPOX	8,11
vWA	16

Web pages

Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; JCRB; -; https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm

Publications

PubMed=8314315; DOI=10.1002/ijc.2910560226
Toshiro Inagaki, Satoshi Matsuwari, Rei Takahashi, Kei-kichi Shimada, Kimiko Fujie, Sakan Maeda;
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references

Cell line collections (Providers)

JCRB; JCRB0127
JCRB; NIHS0166 - Discontinued

Cell line databases/resources

cancercelllines; CVCL_2789

Anatomy/cell type resources

BTO; BTO_0005969

Biological sample resources

BioSample; SAMN03151615
BioSample; SAMN03470802

Encyclopedic resources

Wikidata; Q54900342

Polymorphism and mutation databases

Cosmic; 753571
Cosmic; 1120706
IARC_TP53; 2969

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number