AC   CVCL_2789
SY   KOSC3; Kobe university Oral Squamous Cell culture-3
DR   BTO; BTO:0005969
DR   BioSample; SAMN03151615
DR   BioSample; SAMN03470802
DR   Cosmic; 753571
DR   Cosmic; 1120706
DR   IARC_TP53; 2969
DR   Wikidata; Q54900342
RX   PubMed=8314315;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a Ca9-22 derivative (PubMed=20143388). Originally thought to originate from a 72 year old female patient with a lower-gingiva squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00324.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=8314315).
CC   Discontinued: JCRB; NIHS0166; true.
CC   Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
ST   Source(s): JCRB
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 9,10
ST   D5S818: 12
ST   D7S820: 11,13
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1102 ! Ca9-22
SX   Male
AG   43Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 25
RX   PubMed=8314315; DOI=10.1002/ijc.2910560226;
RA   Inagaki T., Matsuwari S., Takahashi R., Shimada K.-K., Fujie K.,
RA   Maeda S.;
RT   "Establishment of human oral-cancer cell lines (KOSC-2 and -3)
RT   carrying p53 and c-myc abnormalities by geneticin treatment.";
RL   Int. J. Cancer 56:301-308(1994).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).