ID   KOSC-3
AC   CVCL_2789
SY   KOSC3; Kobe university Oral Squamous Cell culture-3
DR   BTO; BTO_0005969
DR   BioSample; SAMN03151615
DR   BioSample; SAMN03470802
DR   cancercelllines; CVCL_2789
DR   Cosmic; 753571
DR   Cosmic; 1120706
DR   IARC_TP53; 2969
DR   JCRB; JCRB0127
DR   JCRB; NIHS0166
DR   Wikidata; Q54900342
RX   PubMed=8314315;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; JCRB; -; https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm
CC   Problematic cell line: Contaminated. Shown to be a Ca9-22 derivative (PubMed=20143388). Originally thought to originate from a 72 year old female patient with a lower-gingiva squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00324.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=8314315).
CC   Discontinued: JCRB; NIHS0166; true.
CC   Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
ST   Source(s): JCRB=JCRB0127
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 9,10
ST   D5S818: 12
ST   D7S820: 11,13
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1102 ! Ca9-22
SX   Male
AG   43Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=8314315; DOI=10.1002/ijc.2910560226;
RA   Inagaki, Toshiro
RA   Matsuwari, Satoshi
RA   Takahashi, Rei
RA   Shimada, Kei-kichi
RA   Fujie, Kimiko
RA   Maeda, Sakan
RT   "Establishment of human oral-cancer cell lines (KOSC-2 and -3)
RT   carrying p53 and c-myc abnormalities by geneticin treatment.";
RL   Int. J. Cancer 56:301-308(1994).
//