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Cellosaurus VP229 (CVCL_2754)

[Text version]
Cell line name VP229
Synonyms VP 229; BrCL18
Accession CVCL_2754
Resource Identification Initiative To cite this cell line use: VP229 (RRID:CVCL_2754)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; miRNA profiling; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Hemizygous (PubMed=10700188).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Unspecified (PubMed=10700188; DepMap=ACH-001419).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2755 ! VP267
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001419; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133818,25
D3S135816,18
D5S81811
D7S82010,12
D8S117910,13
D13S31711,13
D16S53911,12
D18S5116
D19S43313
D21S1129
FGA18
Penta D10
Penta E13,17
TH017
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/VP229.html
Publications

PubMed=8877005; DOI=10.1007/BF01806153
H. Morag McCallum, Gordon W. Lowther;
Long-term culture of primary breast cancer in defined medium.
Breast Cancer Res. Treat. 39:247-259(1996)

PubMed=10700188; DOI=10.1038/73536
Simon Andrew Gayther, Sarah J. Batley, Lori Linger, Andrew J. Bannister, Karen Thorpe, Suet-Feung Chin, Yataro Daigo, Paul Russell, Annie Wilson, Heidi M. Sowter, Joy Dorothy Ann Delhanty ...Show all 14 authors... , Bruce Anthony John Ponder, Tony Kouzarides, Carlos Caldas; Show fewer authors
Mutations truncating the EP300 acetylase in human cancers.
Nat. Genet. 24:300-303(2000)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781
Jeffrey M. Davidson, Kylie Louise Gorringe, Suet-Feung Chin, Beatrice Orsetti, C. Besret, Celine Courtay-Cahen, Ian Roberts, Charles Theillet, Carlos Caldas, Paul A.W. Edwards;
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=12800145; DOI=10.1002/gcc.10218
Jose Adelaide, Huai-En Huang, Anne Murati, Amber E. Alsop, Beatrice Orsetti, Marie-Joelle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Celine Basset, Celine Courtay-Cahen ...Show all 16 authors... , Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul A.W. Edwards, Max Chaffanet; Show fewer authors
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ECACC; 05092804
Cell line databases/resources cancercelllines; CVCL_2754
Cell_Model_Passport; SIDM01826
DepMap; ACH-001419
Biological sample resources BioSample; SAMN03472874
Encyclopedic resources Wikidata; Q54993312
Gene expression databases GEO; GSM115113
GEO; GSM217608
GEO; GSM219888
Polymorphism and mutation databases Cosmic; 1523834
Progenetix; CVCL_2754
Sequence databases EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26