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Cellosaurus UM-UC-7 (CVCL_2752)

[Text version]
Cell line name UM-UC-7
Synonyms UMUC7; University of Michigan-Urothelial Carcinoma-7
Accession CVCL_2752
Resource Identification Initiative To cite this cell line use: UM-UC-7 (RRID:CVCL_2752)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: UBC-40 urothelial bladder cancer cell line index.
Doubling time: 41 hours (PubMed=3761468).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (DepMap=ACH-001415).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001415; ECACC=08090504

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815
D5S81812
D7S82010,11
D8S117914
D13S3178,12 (DepMap=ACH-001415)
12 (ECACC=08090504)
D16S53910,11
D18S5113
D21S1131,32
FGA20,22
Penta D12,13
Penta E7
TH019
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1
Herbert Barton Grossman, Gary Wedemeyer, Li-Qin Ren, Golder N. Wilson, Beth Cox;
Improved growth of human urothelial carcinoma cell cultures.
J. Urol. 136:953-959(1986)

PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731
Hong-Seok Park, Weon Seo Park, Jolanta Bondaruk, Noriyoshi Tanaka, Hiroshi Katayama, Sangkyou Lee, Philippe E. Spiess, Jordan R. Steinberg, Zhi Wang, Ruth L. Katz, Colin Padraic Neal Dinney ...Show all 18 authors... , Keren J. Elias, Yair Lotan, Rizwan C. Naeem, Keith Baggerly, Subrata Sen, Herbert Barton Grossman, Bogdan Czerniak; Show fewer authors
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
J. Natl. Cancer Inst. 100:1401-1411(2008)

PubMed=23401075; DOI=10.1002/path.4176
Ya-Nan Guo, Yvonne Chekaluk, Jian-Ming Zhang, Jin-Yan Du, Nathanael S. Gray, Chin-Lee Wu, David Joseph Kwiatkowski;
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
J. Pathol. 230:17-27(2013)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Yves Allory, Willemien Beukers, Ana Sagrera, Marta Flandez, Miriam Marques, Mirari Marquez, Kirstin A. van der Keur, Lars Dyrskjot, Irene Lurkin, Marcel Vermeij, Alfredo Carrato ...Show all 24 authors... , Josep Lloreta, Jose A. Lorente, Enrique Carrillo-de-Santa-Pau, Roy G. Masius, Manolis Kogevinas, Ewout Willem Steyerberg, Angela A.G. van Tilborg, Cheno Abas, Torben Falck Orntoft, Tahlita C.M. Zuiverloon, Nuria Malats, Ellen C. Zwarthoff, Francisco X. Real; Show fewer authors
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) CancerTools; 160438
ECACC; 08090504 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2752
Cell_Model_Passport; SIDM01402
DepMap; ACH-001415
Encyclopedic resources Wikidata; Q54990994
Gene expression databases GEO; GSM1567865
GEO; GSM1574564
Polymorphism and mutation databases Cosmic; 1927296
Cosmic; 1938704
Cosmic; 2037970
Cosmic; 2700985
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29