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Cellosaurus UM-UC-4 (CVCL_2749)

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Cell line name UM-UC-4
Synonyms UMUC4; University of Michigan-Urothelial Carcinoma-4
Accession CVCL_2749
Resource Identification Initiative To cite this cell line use: UM-UC-4 (RRID:CVCL_2749)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: UBC-40 urothelial bladder cancer cell line index.
Doubling time: 32 hours (PubMed=3761468).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Arg (c.389T>G); Zygosity=Unspecified (DepMap=ACH-001410).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001410; ECACC=08090501

Markers:
AmelogeninX
CSF1PO11
D3S135815,16
D5S81811
D7S8209,13
D8S117914
D13S3179
D16S53913
D18S5116
D21S1129
FGA24
Penta D12
Penta E12,13
TH019.3
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1
Herbert Barton Grossman, Gary Wedemeyer, Li-Qin Ren, Golder N. Wilson, Beth Cox;
Improved growth of human urothelial carcinoma cell cultures.
J. Urol. 136:953-959(1986)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) CancerTools; 160435
ECACC; 08090501 - Discontinued
Cell line databases/resources Cell_Model_Passport; SIDM01910
DepMap; ACH-001410
CRISP screens repositories BioGRID_ORCS_Cell_line; 1827
Encyclopedic resources Wikidata; Q54990991
Gene expression databases GEO; GSM1574566
GEO; GSM1574569
Polymorphism and mutation databases Cosmic; 1938701
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25