ID   UM-UC-4
AC   CVCL_2749
SY   UMUC4; University of Michigan-Urothelial Carcinoma-4
DR   BioGRID_ORCS_Cell_line; 1827
DR   CancerTools; 160435
DR   Cell_Model_Passport; SIDM01910
DR   Cosmic; 1938701
DR   DepMap; ACH-001410
DR   ECACC; 08090501
DR   GEO; GSM1574566
DR   GEO; GSM1574569
DR   Wikidata; Q54990991
RX   PubMed=3761468;
RX   PubMed=25997541;
RX   PubMed=29732388;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Doubling time: 32 hours (PubMed=3761468).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Arg (c.389T>G); Zygosity=Unspecified (DepMap=ACH-001410).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ECACC; 08090501; true.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): DepMap=ACH-001410; ECACC=08090501
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9
ST   D16S539: 13
ST   D18S51: 16
ST   D21S11: 29
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 9,13
ST   D8S1179: 14
ST   FGA: 24
ST   Penta D: 12
ST   Penta E: 12,13
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,19
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350;
RA   Zuiverloon, Tahlita C.M.
RA   de Jong, Florus Christiaan
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang Arthur
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1;
RA   Grossman, Herbert Barton
RA   Wedemeyer, Gary
RA   Ren, Li-Qin
RA   Wilson, Golder N.
RA   Cox, Beth
RT   "Improved growth of human urothelial carcinoma cell cultures.";
RL   J. Urol. 136:953-959(1986).
//