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Cellosaurus UM-UC-14 (CVCL_2747)

[Text version]
Cell line name UM-UC-14
Synonyms UMUC-14; UM-UC14; UMUC14; University of Michigan-Urothelial Carcinoma-14
Accession CVCL_2747
Resource Identification Initiative To cite this cell line use: UM-UC-14 (RRID:CVCL_2747)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: UBC-40 urothelial bladder cancer cell line index.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Kidney, renal pelvis; UBERON=UBERON_0001224.
Sequence variations
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Unspecified (DepMap=ACH-001408).
Disease Renal pelvis carcinoma (NCIt: C6142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001408; ECACC=08090509

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135814,17
D5S81811,12
D7S8209,12
D8S117913,15
D13S31712
D16S53912,13
D18S5112,15
D21S1130.2,31.2
FGA24,25
Penta D9,14
Penta E12,18
TH019.3
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X
Sabichi A.L., Keyhani A., Tanaka N., Delacerda J., Lee I.-L., Zou C.-P., Zhou J.-H., Benedict W.F., Grossman H.B.
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.
J. Urol. 175:1133-1137(2006)

PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731
Park H.-S., Park W.S., Bondaruk J., Tanaka N., Katayama H., Lee S., Spiess P.E., Steinberg J.R., Wang Z., Katz R.L., Dinney C.P.N., Elias K.J., Lotan Y., Naeem R.C., Baggerly K., Sen S., Grossman H.B., Czerniak B.
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
J. Natl. Cancer Inst. 100:1401-1411(2008)

PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455
Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
J. Urol. 181:2737-2748(2009)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
Hurst C.D., Platt F.M., Knowles M.A.
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Eur. Urol. 65:367-369(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S.J., Valencia A., Real F.X.
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) CancerTools; 160443
ECACC; 08090509 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2747
Cell_Model_Passport; SIDM01405
DepMap; ACH-001408
Anatomy/cell type resources BTO; BTO:0004991
Encyclopedic resources Wikidata; Q54990977
Gene expression databases GEO; GSM136259
GEO; GSM1574586
GEO; GSM1574587
Polymorphism and mutation databases Cosmic; 1082653
Cosmic; 1302360
Cosmic; 1938709
Cosmic; 2037965
Cosmic; 2050469
Cosmic; 2057447
Cosmic; 2212695
Cosmic; 2444231
Cosmic; 2700990
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number27