ID   UM-UC-14
AC   CVCL_2747
SY   UMUC-14; UM-UC14; UMUC14; University of Michigan-Urothelial Carcinoma-14
DR   BTO; BTO_0004991
DR   cancercelllines; CVCL_2747
DR   CancerTools; 160443
DR   Cell_Model_Passport; SIDM01405
DR   Cosmic; 1082653
DR   Cosmic; 1302360
DR   Cosmic; 1938709
DR   Cosmic; 2037965
DR   Cosmic; 2050469
DR   Cosmic; 2057447
DR   Cosmic; 2212695
DR   Cosmic; 2444231
DR   Cosmic; 2700990
DR   DepMap; ACH-001408
DR   ECACC; 08090509
DR   GEO; GSM136259
DR   GEO; GSM1574586
DR   GEO; GSM1574587
DR   Wikidata; Q54990977
RX   PubMed=16469639;
RX   PubMed=18812553;
RX   PubMed=19375735;
RX   PubMed=24018021;
RX   PubMed=24035680;
RX   PubMed=25997541;
RX   PubMed=29732388;
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Unspecified (DepMap=ACH-001408).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ECACC; 08090509; true.
CC   Derived from site: In situ; Kidney, renal pelvis; UBERON=UBERON_0001224.
ST   Source(s): DepMap=ACH-001408; ECACC=08090509
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 12,13
ST   D18S51: 12,15
ST   D21S11: 30.2,31.2
ST   D3S1358: 14,17
ST   D5S818: 11,12
ST   D7S820: 9,12
ST   D8S1179: 13,15
ST   FGA: 24,25
ST   Penta D: 9,14
ST   Penta E: 12,18
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C6142; Renal pelvis carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang A.
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350;
RA   Zuiverloon, Tahlita C.M.
RA   de Jong, Florus C.
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052;
RA   Allory, Yves
RA   Beukers, Willemien
RA   Sagrera, Ana
RA   Flandez, Marta
RA   Marques, Miriam
RA   Marquez, Mirari
RA   van der Keur, Kirstin A.
RA   Dyrskjot, Lars
RA   Lurkin, Irene
RA   Vermeij, Marcel
RA   Carrato, Alfredo
RA   Lloreta, Josep
RA   Lorente, Jose A.
RA   Carrillo-de-Santa-Pau, Enrique
RA   Masius, Roy G.
RA   Kogevinas, Manolis
RA   Steyerberg, Ewout Willem
RA   van Tilborg, Angela A.G.
RA   Abas, Cheno
RA   Orntoft, Torben Falck
RA   Zuiverloon, Tahlita C.M.
RA   Malats, Nuria
RA   Zwarthoff, Ellen C.
RA   Real, Francisco X.
RT   "Telomerase reverse transcriptase promoter mutations in bladder
RT   cancer: high frequency across stages, detection in urine, and lack of
RT   association with outcome.";
RL   Eur. Urol. 65:360-366(2014).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst, Carolyn D.
RA   Platt, Fiona M.
RA   Knowles, Margaret A.
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
RX   PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731;
RA   Park, Hong-Seok
RA   Park, Weon Seo
RA   Bondaruk, Jolanta
RA   Tanaka, Noriyoshi
RA   Katayama, Hiroshi
RA   Lee, Sangkyou
RA   Spiess, Philippe E.
RA   Steinberg, Jordan R.
RA   Wang, Zhi
RA   Katz, Ruth L.
RA   Dinney, Colin Padraic Neal
RA   Elias, Keren J.
RA   Lotan, Yair
RA   Naeem, Rizwan C.
RA   Baggerly, Keith
RA   Sen, Subrata
RA   Grossman, Herbert Barton
RA   Czerniak, Bogdan
RT   "Quantitation of Aurora kinase A gene copy number in urine sediments
RT   and bladder cancer detection.";
RL   J. Natl. Cancer Inst. 100:1401-1411(2008).
//
RX   PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X;
RA   Sabichi, Anita Lyn
RA   Keyhani, Afsaneh
RA   Tanaka, Noriyoshi
RA   Delacerda, Jorge
RA   Lee, I-Ling
RA   Zou, Chang-Ping
RA   Zhou, Jian-Hua
RA   Benedict, William F.
RA   Grossman, Herbert Barton
RT   "Characterization of a panel of cell lines derived from urothelial
RT   neoplasms: genetic alterations, growth in vivo and the relationship of
RT   adenoviral mediated gene transfer to coxsackie adenovirus receptor
RT   expression.";
RL   J. Urol. 175:1133-1137(2006).
//
RX   PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455;
RA   Chiong, Edmund
RA   Dadbin, Ali
RA   Harris, Loleta D.
RA   Sabichi, Anita Lyn
RA   Grossman, Herbert Barton
RT   "The use of short tandem repeat profiling to characterize human
RT   bladder cancer cell lines.";
RL   J. Urol. 181:2737-2748(2009).
//