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Cellosaurus PEA2 (CVCL_2683)

[Text version]
Cell line name PEA2
Accession CVCL_2683
Resource Identification Initiative To cite this cell line use: PEA2 (RRID:CVCL_2683)
Comments Part of: MD Anderson Cell Lines Project.
Part of: OCCP ovarian cancer cell line panel.
Doubling time: 66 hours (PubMed=3167863).
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
Disease Ovarian cystadenocarcinoma (NCIt: C5228)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2682 ! PEA1
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=10032307; PubMed=22183581; PubMed=25230021; PubMed=30485824

Markers:
AmelogeninX
CSF1PO11,14
D2S133819
D3S135816
D5S81811,13
D7S82010,12
D8S117914
D13S3178
D16S53912,13
D18S5117
D19S43312,13
D21S1130
FGA25
Penta D13,15
Penta E7,13
TH019
TPOX8 (ECACC=10032307)
8,12 (PubMed=22183581; PubMed=25230021; PubMed=30485824)
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3167863
Simon P. Langdon, Sandra S. Lawrie, Frances G. Hay, Mary M. Hawkes, Amanda McDonald, Ian P. Hayward, Dick J. Schol, Jo Hilgers, Robert C.F. Leonard, John F. Smyth;
Characterization and properties of nine human ovarian adenocarcinoma cell lines.
Cancer Res. 48:6166-6172(1988)

PubMed=20581869; DOI=10.1038/onc.2010.245; PMCID=PMC2933510
Susanna L. Cooke, Charlotte Kiu Yan Ng, Nataliya Melnyk, Maria J. Garcia, Thomas James Hardcastle, Jillian Temple, Simon P. Langdon, David G. Huntsman, James D. Brenton;
Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.
Oncogene 29:4905-4913(2010)

PubMed=22183581; DOI=10.1002/path.3980
Charlotte Kiu Yan Ng, Susanna L. Cooke, Kevin L. Howe, Scott Newman, Jian Xian, Jillian Temple, Elizabeth M. Batty, Jessica C.M. Pole, Simon P. Langdon, Paul A.W. Edwards, James D. Brenton;
The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.
J. Pathol. 226:703-712(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Jose Suarez Saiz ...Show all 19 authors... , Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny I. Drapkin, Laurie Ailles, Anne-Marie Mes-Masson, Robert Rottapel; Show fewer authors
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

PubMed=35028612; DOI=10.1016/j.xcrm.2021.100471; PMCID=PMC8714940
Dong-Qing Huang, Shrabanti Chowdhury, Hong Wang, Sara R. Savage, Richard G. Ivey, Jacob J. Kennedy, Jeffrey R. Whiteaker, Chen-Wei Lin, Xiao-Nan Hou, Ann L. Oberg, Melissa C. Larson ...Show all 30 authors... , Najmeh Eskandari, Davide A. Delisi, Saverio Gentile, Catherine J. Huntoon, Uliana J. Voytovich, Zahra J. Shire, Qing Yu, Steven P. Gygi, Andrew Norbert Hoofnagle, Zachary T. Herbert, Travis D. Lorentzen, Anna Calinawan, Larry M. Karnitz, S. John Weroha, Scott H. Kaufmann, Bing Zhang, Pei Wang, Michael J. Birrer, Amanda Grace Paulovich; Show fewer authors
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Cell Rep. Med. 2:100471.1-100471.32(2021)

Cross-references
Cell line collections (Providers) CancerTools; 151679
ECACC; 10032307 - Discontinued
Ximbio; 151679
Cell line databases/resources cancercelllines; CVCL_2683
Cell_Model_Passport; SIDM01425
Encyclopedic resources Wikidata; Q54946893
Gene expression databases GEO; GSM459852
GEO; GSM659401
GEO; GSM2474997
GEO; GSM4973220
GEO; GSM4973226
GEO; GSM4973232
GEO; GSM4973238
GEO; GSM4973244
GEO; GSM4973250
GEO; GSM4973256
GEO; GSM4973262
GEO; GSM4973268
Polymorphism and mutation databases Progenetix; CVCL_2683
Proteomic databases PRIDE; PXD020764
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29