Cellosaurus cell line OKT 3 (CVCL

Cellosaurus OKT 3 (CVCL_2665)

Cross-references
Cell line name	OKT 3
Synonyms	OKT3
Accession	CVCL_2665
Resource Identification Initiative	To cite this cell line use: OKT 3 (RRID:CVCL_2665)
Comments	Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8001. Biotechnology: The monoclonal antibody produced by this hybridoma was used as an immunosuppressant drug under the name Muromonab-CD3 (Orthoclone OKT3). Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized teplizumab (MGA031) therapeutic antibody. Monoclonal antibody isotype: IgG2a. Monoclonal antibody target: UniProtKB; P07766; Human CD3E. Anecdotal: OKT3 was the first monoclonal antibody to be approved for clinical use in humans.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy	Parent: CVCL_3412 (P3X63Ag8U.1)
Category	Hybridoma
Publications	PubMed=314668; DOI=10.1126/science.314668 Patrick C. Kung, Gideon Goldstein, Ellis L. Reinherz, Stuart Franklin Schlossman; Monoclonal antibodies defining distinctive human T cell surface antigens. Science 206:347-349(1979) Patent=US4361549 Patrick C. Kung, Gideon Goldstein; Complement-fixing monoclonal antibody to human T cells, and methods of preparing same. Patent number US4361549, 30-Nov-1982 DOI=10.1007/978-1-4899-1236-7_4 Patricia E. Rao, Daniel J. Kroon; Orthoclone OKT3. (In book chapter) Stability and characterization of protein and peptide drugs. Pharmaceutical Biotechnology, Vol. 5; Wang, Y. John & Pearlman, Rodney (eds.); pp.135-158; Springer; Boston; USA (1993)
Cell line collections (Providers)	ATCC; CRL-8001 BCRC; 60154 CLS; 300499 ECACC; 86022706 IZSLER; BS Hy 12 NCBI_Iran; H104 TKG; TKG 0235 - Discontinued
Cell line databases/resources	CLO; CLO_0008252 CLDB; cl5239 CCRID; 3101ETCHYB58
Biological sample resources	ABCD; ABCD_AC852
Encyclopedic resources	Wikidata; Q54931950
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	15