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Cellosaurus MM170 (CVCL_2603)

[Text version]
Cell line name MM170
Synonyms MM 170
Accession CVCL_2603
Resource Identification Initiative To cite this cell line use: MM170 (RRID:CVCL_2603)
Comments Problematic cell line: Contaminated. Presence of a second cell line in earliest stock not picked up due to low level of contamination (CBA=CBA-1346).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA=CBA-1346

Markers:
AmelogeninX
CSF1PO12
D2S133820,24
D3S135815
D5S81811,12
D7S8208,12
D8S117913,14
D13S3178,9
D16S53910,12
D18S5113,17
D19S43314
D21S1128,31.2
FGA22,25
TH017
TPOX8,12
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=830403
Patricia D. Goss, Peter G. Parsons;
The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.
Cancer Res. 37:152-156(1977)

PubMed=294576; DOI=10.3109/00313027909059039
Pauline D. Muir, Friedrich Walter Gunz;
A cytogenetic study of eight human melanoma cell lines.
Pathology 11:597-606(1979)

PubMed=460945; DOI=10.3109/00313027909061945
John Hebden Pope, Leanne E. Morrison, Denis J. Moss, Peter G. Parsons, Regis Mary Dunne;
Human malignant melanoma cell lines.
Pathology 11:191-195(1979)

PubMed=6187441
Peter G. Parsons, Peter Musk, Patricia D. Goss, John Leah;
Effects of calcium depletion on human cells in vitro and the anomalous behavior of the human melanoma cell line MM170.
Cancer Res. 43:2081-2087(1983)

PubMed=4059365; DOI=10.1111/j.1751-1097.1985.tb08944.x
Peter G. Parsons, Ian P. Hayward;
Inhibition of DNA repair synthesis by sunlight.
Photochem. Photobiol. 42:287-293(1985)

PubMed=1697409
Georgia Chenevix-Trench, Nicholas Gordon Martin, Kay Adrian Oswald Ellem;
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.
Oncogene 5:1187-1193(1990)

PubMed=9354451
Marina Castellano, Pamela M. Pollock, Marilyn K. Walters, Louise E. Sparrow, Louise M. Down, Brian G. Gabrielli, Peter G. Parsons, Nicholas K. Hayward;
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648
Shuraila Francisca Zerp, Andrea van Elsas, Lucy T.C. Peltenburg, Peter I. Schrier;
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Sandra Pavey, Peter Johansson, Leisl Packer, Jennifer Taylor, Mitchell S. Stark, Pamela M. Pollock, Graeme J. Walker, Glen M. Boyle, Ursula Harper, Sarah-Jane Cozzi, Katherine Hansen ...Show all 20 authors... , Laura Yudt, Chris Schmidt, Peter Hersey, Kay Adrian Oswald Ellem, Michael G.E. O'Rourke, Peter G. Parsons, Paul S. Meltzer, Markus Ringner, Nicholas K. Hayward; Show fewer authors
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Peter Johansson, Sandra Pavey, Nicholas K. Hayward;
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Ken Dutton-Regester, Darryl Irwin, Priscilla Hunt, Lauren G. Aoude, Varsha Tembe, Gulietta M. Pupo, Cathy Lanagan, Candace D. Carter, Linda O'Connor, Michael O'Rourke, Richard Anthony Scolyer ...Show all 15 authors... , Graham J. Mann, Christopher W. Schmidt, Adrian Herington, Nicholas K. Hayward; Show fewer authors
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=23039341; DOI=10.1186/1476-4598-11-75; PMCID=PMC3554420
Sara A. Byron, David C. Loch, Candice L. Wellens, Andreas Wortmann, Jia-Yi Wu, John Wang, Kenichi Nomoto, Pamela M. Pollock;
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Mol. Cancer 11:75.1-75.15(2012)

Cross-references
Cell line collections (Providers) CBA; CBA-1346 - Discontinued
ECACC; 10092315
Cell line databases/resources cancercelllines; CVCL_2603
Biological sample resources BioSample; SAMN07624424
Encyclopedic resources Wikidata; Q54906067
Gene expression databases GEO; GSM162905
Polymorphism and mutation databases Cosmic; 889013
Cosmic; 928712
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26