ID   MM170
AC   CVCL_2603
SY   MM 170
DR   BioSample; SAMN07624424
DR   cancercelllines; CVCL_2603
DR   CBA; CBA-1346
DR   Cosmic; 889013
DR   Cosmic; 928712
DR   ECACC; 10092315
DR   GEO; GSM162905
DR   Wikidata; Q54906067
RX   PubMed=294576;
RX   PubMed=460945;
RX   PubMed=830403;
RX   PubMed=1697409;
RX   PubMed=4059365;
RX   PubMed=6187441;
RX   PubMed=9354451;
RX   PubMed=10070891;
RX   PubMed=15048078;
RX   PubMed=17516929;
RX   PubMed=22383533;
RX   PubMed=23039341;
CC   Problematic cell line: Contaminated. Presence of a second cell line in earliest stock not picked up due to low level of contamination (CBA=CBA-1346).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=9354451).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=15048078; PubMed=22383533).
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: CBA; CBA-1346; true.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): CBA=CBA-1346
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,9
ST   D16S539: 10,12
ST   D18S51: 13,17
ST   D19S433: 14
ST   D21S11: 28,31.2
ST   D2S1338: 20,24
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 13,14
ST   FGA: 22,25
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 18,19
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=830403;
RA   Goss, Patricia D.
RA   Parsons, Peter G.
RT   "The effect of hyperthermia and melphalan on survival of human
RT   fibroblast strains and melanoma cell lines.";
RL   Cancer Res. 37:152-156(1977).
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester, Ken
RA   Irwin, Darryl
RA   Hunt, Priscilla
RA   Aoude, Lauren G.
RA   Tembe, Varsha
RA   Pupo, Gulietta M.
RA   Lanagan, Cathy
RA   Carter, Candace D.
RA   O'Connor, Linda
RA   O'Rourke, Michael
RA   Scolyer, Richard Anthony
RA   Mann, Graham J.
RA   Schmidt, Christopher W.
RA   Herington, Adrian
RA   Hayward, Nicholas K.
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//
RX   PubMed=23039341; DOI=10.1186/1476-4598-11-75; PMCID=PMC3554420;
RA   Byron, Sara A.
RA   Loch, David C.
RA   Wellens, Candice L.
RA   Wortmann, Andreas
RA   Wu, Jia-Yi
RA   Wang, John
RA   Nomoto, Kenichi
RA   Pollock, Pamela M.
RT   "Sensitivity to the MEK inhibitor E6201 in melanoma cells is
RT   associated with mutant BRAF and wildtype PTEN status.";
RL   Mol. Cancer 11:75.1-75.15(2012).
//
RX   PubMed=294576; DOI=10.3109/00313027909059039;
RA   Muir, Pauline D.
RA   Gunz, Friedrich Walter
RT   "A cytogenetic study of eight human melanoma cell lines.";
RL   Pathology 11:597-606(1979).
//
RX   PubMed=9354451;
RA   Castellano, Marina
RA   Pollock, Pamela M.
RA   Walters, Marilyn K.
RA   Sparrow, Louise E.
RA   Down, Louise M.
RA   Gabrielli, Brian G.
RA   Parsons, Peter G.
RA   Hayward, Nicholas K.
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey, Sandra
RA   Johansson, Peter
RA   Packer, Leisl
RA   Taylor, Jennifer
RA   Stark, Mitchell S.
RA   Pollock, Pamela M.
RA   Walker, Graeme J.
RA   Boyle, Glen M.
RA   Harper, Ursula
RA   Cozzi, Sarah-Jane
RA   Hansen, Katherine
RA   Yudt, Laura
RA   Schmidt, Chris
RA   Hersey, Peter
RA   Ellem, Kay Adrian Oswald
RA   O'Rourke, Michael G.E.
RA   Parsons, Peter G.
RA   Meltzer, Paul S.
RA   Ringner, Markus
RA   Hayward, Nicholas K.
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=460945; DOI=10.3109/00313027909061945;
RA   Pope, John Hebden
RA   Morrison, Leanne E.
RA   Moss, Denis J.
RA   Parsons, Peter G.
RA   Dunne, Regis Mary
RT   "Human malignant melanoma cell lines.";
RL   Pathology 11:191-195(1979).
//
RX   PubMed=6187441;
RA   Parsons, Peter G.
RA   Musk, Peter
RA   Goss, Patricia D.
RA   Leah, John
RT   "Effects of calcium depletion on human cells in vitro and the
RT   anomalous behavior of the human melanoma cell line MM170.";
RL   Cancer Res. 43:2081-2087(1983).
//
RX   PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x;
RA   Johansson, Peter
RA   Pavey, Sandra
RA   Hayward, Nicholas K.
RT   "Confirmation of a BRAF mutation-associated gene expression signature
RT   in melanoma.";
RL   Pigment Cell Res. 20:216-221(2007).
//
RX   PubMed=1697409;
RA   Chenevix-Trench, Georgia
RA   Martin, Nicholas Gordon
RA   Ellem, Kay Adrian Oswald
RT   "Gene expression in melanoma cell lines and cultured melanocytes:
RT   correlation between levels of c-src-1, c-myc and p53.";
RL   Oncogene 5:1187-1193(1990).
//
RX   PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648;
RA   Zerp, Shuraila Francisca
RA   van Elsas, Andrea
RA   Peltenburg, Lucy T.C.
RA   Schrier, Peter I.
RT   "p53 mutations in human cutaneous melanoma correlate with sun exposure
RT   but are not always involved in melanomagenesis.";
RL   Br. J. Cancer 79:921-926(1999).
//
RX   PubMed=4059365; DOI=10.1111/j.1751-1097.1985.tb08944.x;
RA   Parsons, Peter G.
RA   Hayward, Ian P.
RT   "Inhibition of DNA repair synthesis by sunlight.";
RL   Photochem. Photobiol. 42:287-293(1985).
//