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Cellosaurus MM127 (CVCL_2601)

[Text version]
Cell line name MM127
Synonyms MM-127
Accession CVCL_2601
Resource Identification Initiative To cite this cell line use: MM127 (RRID:CVCL_2601)
Comments Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a metastatic melanoma. Lacks the expression of three protein markers: S100, HMB-45 and Melan-A commonly found in melanoma cell lines (PubMed=27087056). Has a CTNNB1 mutation not seen in other melanoma cell lines (PubMed=11930117).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA=CBA-1344; PubMed=27087056

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819,20
D3S135815,17
D5S81811,12
D7S82010,11 (CBA=CBA-1344)
10,12 (PubMed=27087056)
D8S117914,15
D13S31712,13
D16S53910,13
D18S5115,20
D19S43313,14
D21S1129
FGA19,20
Penta D10
Penta E5,10
TH018,9
TPOX11,12
vWA16,18

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Publications

PubMed=830403
Patricia D. Goss, Peter G. Parsons;
The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.
Cancer Res. 37:152-156(1977)

PubMed=294576; DOI=10.3109/00313027909059039
Pauline D. Muir, Friedrich Walter Gunz;
A cytogenetic study of eight human melanoma cell lines.
Pathology 11:597-606(1979)

PubMed=460945; DOI=10.3109/00313027909061945
John Hebden Pope, Leanne E. Morrison, Denis J. Moss, Peter G. Parsons, Regis Mary Dunne;
Human malignant melanoma cell lines.
Pathology 11:191-195(1979)

PubMed=1697409
Georgia Chenevix-Trench, Nicholas Gordon Martin, Kay Adrian Oswald Ellem;
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.
Oncogene 5:1187-1193(1990)

PubMed=9354451
Marina Castellano, Pamela M. Pollock, Marilyn K. Walters, Louise E. Sparrow, Louise M. Down, Brian G. Gabrielli, Peter G. Parsons, Nicholas K. Hayward;
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648
Shuraila Francisca Zerp, Andrea van Elsas, Lucy T.C. Peltenburg, Peter I. Schrier;
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=11930117; DOI=10.1097/00008390-200204000-00013
Pamela M. Pollock, Nicholas K. Hayward;
Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines.
Melanoma Res. 12:183-186(2002)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Sandra Pavey, Peter Johansson, Leisl Packer, Jennifer Taylor, Mitchell S. Stark, Pamela M. Pollock, Graeme J. Walker, Glen M. Boyle, Ursula Harper, Sarah-Jane Cozzi, Katherine Hansen ...Show all 20 authors... , Laura Yudt, Chris Schmidt, Peter Hersey, Kay Adrian Oswald Ellem, Michael G.E. O'Rourke, Peter G. Parsons, Paul S. Meltzer, Markus Ringner, Nicholas K. Hayward; Show fewer authors
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Mitchell S. Stark, Nicholas K. Hayward;
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Peter Johansson, Sandra Pavey, Nicholas K. Hayward;
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Ken Dutton-Regester, Darryl Irwin, Priscilla Hunt, Lauren G. Aoude, Varsha Tembe, Gulietta M. Pupo, Cathy Lanagan, Candace D. Carter, Linda O'Connor, Michael O'Rourke, Richard Anthony Scolyer ...Show all 15 authors... , Graham J. Mann, Christopher W. Schmidt, Adrian Herington, Nicholas K. Hayward; Show fewer authors
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=27087056; DOI=10.1038/srep24569; PMCID=PMC4834532
Parvathi Haridas, Jacqui A. McGovern, Abhishek S. Kashyap, D.L. Sean McElwain, Matthew J. Simpson;
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Sci. Rep. 6:24569-24569(2016)

Cross-references
Cell line collections (Providers) CBA; CBA-1344
ECACC; 10092314
Cell line databases/resources cancercelllines; CVCL_2601
Cell_Model_Passport; SIDM01356
DepMap; ACH-001563
Biological sample resources BioSample; SAMN07624422
Encyclopedic resources Wikidata; Q54906044
Gene expression databases GEO; GSM78852
GEO; GSM78853
GEO; GSM78854
GEO; GSM78855
GEO; GSM78856
GEO; GSM78857
GEO; GSM162904
GEO; GSM219416
Polymorphism and mutation databases Cosmic; 873569
Cosmic; 889012
Cosmic; 928705
Cosmic; 2159441
Progenetix; CVCL_2601
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26