ID MM127 AC CVCL_2601 SY MM-127 DR BioSample; SAMN07624422 DR cancercelllines; CVCL_2601 DR CBA; CBA-1344 DR Cell_Model_Passport; SIDM01356 DR Cosmic; 873569 DR Cosmic; 889012 DR Cosmic; 928705 DR Cosmic; 2159441 DR DepMap; ACH-001563 DR ECACC; 10092314 DR GEO; GSM78852 DR GEO; GSM78853 DR GEO; GSM78854 DR GEO; GSM78855 DR GEO; GSM78856 DR GEO; GSM78857 DR GEO; GSM162904 DR GEO; GSM219416 DR Progenetix; CVCL_2601 DR Wikidata; Q54906044 RX PubMed=294576; RX PubMed=460945; RX PubMed=830403; RX PubMed=1697409; RX PubMed=9354451; RX PubMed=10070891; RX PubMed=11930117; RX PubMed=15048078; RX PubMed=17363583; RX PubMed=17516929; RX PubMed=22383533; RX PubMed=27087056; CC Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a metastatic melanoma. Lacks the expression of three protein markers: S100, HMB-45 and Melan-A commonly found in melanoma cell lines (PubMed=27087056). Has a CTNNB1 mutation not seen in other melanoma cell lines (PubMed=11930117). CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=9354451; PubMed=17363583). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Unspecified (PubMed=11930117). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Arg (c.37G>C); ClinVar=VCV000013899; Zygosity=Heterozygous (PubMed=15048078; PubMed=17363583; PubMed=22383533). CC Omics: Genomics; Whole exome sequencing. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; CNV analysis. CC Omics: Variations; SNP array analysis. CC Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072. ST Source(s): CBA=CBA-1344; PubMed=27087056 ST Amelogenin: X,Y ST CSF1PO: 10,11 ST D13S317: 12,13 ST D16S539: 10,13 ST D18S51: 15,20 ST D19S433: 13,14 ST D21S11: 29 ST D2S1338: 19,20 ST D3S1358: 15,17 ST D5S818: 11,12 ST D7S820: 10,11 (CBA=CBA-1344) ST D7S820: 10,12 (PubMed=27087056) ST D8S1179: 14,15 ST FGA: 19,20 ST Penta D: 10 ST Penta E: 5,10 ST TH01: 8,9 ST TPOX: 11,12 ST vWA: 16,18 DI NCIt; C3802; Amelanotic melanoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 26 // RX PubMed=830403; RA Goss, Patricia D. RA Parsons, Peter G. RT "The effect of hyperthermia and melphalan on survival of human RT fibroblast strains and melanoma cell lines."; RL Cancer Res. 37:152-156(1977). // RX PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676; RA Dutton-Regester, Ken RA Irwin, Darryl RA Hunt, Priscilla RA Aoude, Lauren G. RA Tembe, Varsha RA Pupo, Gulietta M. RA Lanagan, Cathy RA Carter, Candace D. RA O'Connor, Linda RA O'Rourke, Michael RA Scolyer, Richard Anthony RA Mann, Graham J. RA Schmidt, Christopher W. RA Herington, Adrian RA Hayward, Nicholas K. RT "A high-throughput panel for identifying clinically relevant mutation RT profiles in melanoma."; RL Mol. Cancer Ther. 11:888-897(2012). // RX PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152; RA Stark, Mitchell S. RA Hayward, Nicholas K. RT "Genome-wide loss of heterozygosity and copy number analysis in RT melanoma using high-density single-nucleotide polymorphism arrays."; RL Cancer Res. 67:2632-2642(2007). // RX PubMed=294576; DOI=10.3109/00313027909059039; RA Muir, Pauline D. RA Gunz, Friedrich Walter RT "A cytogenetic study of eight human melanoma cell lines."; RL Pathology 11:597-606(1979). // RX PubMed=9354451; RA Castellano, Marina RA Pollock, Pamela M. RA Walters, Marilyn K. RA Sparrow, Louise E. RA Down, Louise M. RA Gabrielli, Brian G. RA Parsons, Peter G. RA Hayward, Nicholas K. RT "CDKN2A/p16 is inactivated in most melanoma cell lines."; RL Cancer Res. 57:4868-4875(1997). // RX PubMed=15048078; DOI=10.1038/sj.onc.1207563; RA Pavey, Sandra RA Johansson, Peter RA Packer, Leisl RA Taylor, Jennifer RA Stark, Mitchell S. RA Pollock, Pamela M. RA Walker, Graeme J. RA Boyle, Glen M. RA Harper, Ursula RA Cozzi, Sarah-Jane RA Hansen, Katherine RA Yudt, Laura RA Schmidt, Chris RA Hersey, Peter RA Ellem, Kay Adrian Oswald RA O'Rourke, Michael G.E. RA Parsons, Peter G. RA Meltzer, Paul S. RA Ringner, Markus RA Hayward, Nicholas K. RT "Microarray expression profiling in melanoma reveals a BRAF mutation RT signature."; RL Oncogene 23:4060-4067(2004). // RX PubMed=460945; DOI=10.3109/00313027909061945; RA Pope, John Hebden RA Morrison, Leanne E. RA Moss, Denis J. RA Parsons, Peter G. RA Dunne, Regis Mary RT "Human malignant melanoma cell lines."; RL Pathology 11:191-195(1979). // RX PubMed=27087056; DOI=10.1038/srep24569; PMCID=PMC4834532; RA Haridas, Parvathi RA McGovern, Jacqui A. RA Kashyap, Abhishek S. RA McElwain, Donald Leon Sean RA Simpson, Matthew J. RT "Standard melanoma-associated markers do not identify the MM127 RT metastatic melanoma cell line."; RL Sci. Rep. 6:24569.1-24569.6(2016). // RX PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x; RA Johansson, Peter RA Pavey, Sandra RA Hayward, Nicholas K. RT "Confirmation of a BRAF mutation-associated gene expression signature RT in melanoma."; RL Pigment Cell Res. 20:216-221(2007). // RX PubMed=11930117; DOI=10.1097/00008390-200204000-00013; RA Pollock, Pamela M. RA Hayward, Nicholas K. RT "Mutations in exon 3 of the beta-catenin gene are rare in melanoma RT cell lines."; RL Melanoma Res. 12:183-186(2002). // RX PubMed=1697409; RA Chenevix-Trench, Georgia RA Martin, Nicholas Gordon RA Ellem, Kay Adrian Oswald RT "Gene expression in melanoma cell lines and cultured melanocytes: RT correlation between levels of c-src-1, c-myc and p53."; RL Oncogene 5:1187-1193(1990). // RX PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648; RA Zerp, Shuraila Francisca RA van Elsas, Andrea RA Peltenburg, Lucy T.C. RA Schrier, Peter I. RT "p53 mutations in human cutaneous melanoma correlate with sun exposure RT but are not always involved in melanomagenesis."; RL Br. J. Cancer 79:921-926(1999). //