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Cellosaurus MKL-1 (CVCL_2600)

[Text version]
Cell line name MKL-1
Synonyms Mkl-1; MKL1
Accession CVCL_2600
Resource Identification Initiative To cite this cell line use: MKL-1 (RRID:CVCL_2600)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Virology: Contains 3.5 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
Doubling time: ~120 hours (PubMed=3546933); 3 days (PubMed=20444890).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Array-based CGH.
Omics: Deep quantitative proteome analysis.
Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EQ70 (MKL-1 subclone 1)CVCL_EQ71 (MKL-1 subclone 2)
Originate from same individual CVCL_ER19 ! MKL-1-FB
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=30873613

Penta D12,15
Penta E10,14

Run an STR similarity search on this cell line

Rosen S.T., Gould V.E., Salwen H.R., Herst C.V., Le Beau M.M., Lee I., Bauer K., Marder R.J., Andersen R., Kies M.S., Moll R., Franke W.W., Radosevich J.A.
Establishment and characterization of a neuroendocrine skin carcinoma cell line.
Lab. Invest. 56:302-312(1987)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006
Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M., Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R., De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001
Guastafierro A., Feng H., Thant M., Kirkwood J.M., Chang Y., Moore P.S., Shuda M.
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
J. Virol. Methods 187:6-14(2013)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793
Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A., Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=29696010; DOI=10.3389/fmicb.2018.00713
Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.
Characterization of a Merkel cell polyomavirus-positive Merkel cell carcinoma cell line CVG-1.
Front. Microbiol. 9:713.1-713.10(2018)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z
Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M., Mitulovic G.
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Cell line collections (Providers) ECACC; 09111801
Cell line databases/resources Cell_Model_Passport; SIDM01791
DepMap; ACH-001122
Encyclopedic resources Wikidata; Q54905813
Polymorphism and mutation databases Cosmic; 1693072
Cosmic; 1699817
Cosmic; 2273916
Proteomic databases PRIDE; PXD008181
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number18