Cellosaurus logo
expasy logo

Cellosaurus MKL-1 (CVCL_2600)

[Text version]
Cell line name MKL-1
Synonyms Mkl-1; MKL1
Accession CVCL_2600
Resource Identification Initiative To cite this cell line use: MKL-1 (RRID:CVCL_2600)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Virology: Contains 3.5 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
Doubling time: ~120 hours (PubMed=3546933); 3 days (PubMed=20444890).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Exosome.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EQ70 (MKL-1 subclone 1)CVCL_EQ71 (MKL-1 subclone 2)
Originate from same individual CVCL_ER19 ! MKL-1-FB
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): ECACC=09111801; PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815.2
D5S81811,12
D7S8208,11
D8S117910
D13S3178,11
D16S53910,12
D18S5112,18
D21S1130
FGA21,25
Penta D12,15
Penta E10,14
TH019,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=3546933
Steven T. Rosen, Victor E. Gould, Helen R. Salwen, Charles Vincent Herst, Michelle M. Le Beau, Inchul Lee, Kenneth Bauer, Robert J. Marder, Rhonda Andersen, Merrill Stephen Kies, Roland Moll ...Show all 13 authors... , Werner Wilhelm Franke, James A. Radosevich; Show fewer authors
Establishment and characterization of a neuroendocrine skin carcinoma cell line.
Lab. Invest. 56:302-312(1987)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006; PMCID=PMC2374386
Mireille Van Gele, Mourad Kaghad, Joan Helen Leonard, Nadine Van Roy, Jean M. Naeyaert, Marie-Louise Geerts, Simon Van Belle, Veronique F. Cocquyt, Julia A. Bridge, Raf Sciot, Christiane De Wolf-Peeters ...Show all 14 authors... , Anne De Paepe, Daniel Caput, Frank Speleman; Show fewer authors
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=20444890; DOI=10.1128/JVI.02400-09; PMCID=PMC2898224
Roland Houben, Masahiro Shuda, Rita Weinkam, David Schrama, Hui-Chen Feng, Yuan Chang, Patrick S. Moore, Jurgen C. Becker;
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Christian Hafner, Roland Houben, Anne Baeurle, Cathrin Ritter, David Schrama, Michael Landthaler, Jurgen C. Becker;
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:e31255.1-e31255.8(2012)

PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001; PMCID=PMC3606892
Anna Guastafierro, Hui-Chen Feng, Mamie Thant, John Munn Kirkwood, Yuan Chang, Patrick S. Moore, Masahiro Shuda;
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
J. Virol. Methods 187:6-14(2013)

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793; PMCID=PMC5078066
Sonja Hesbacher, Lisa Pfitzer, Katharina Wiedorfer, Sabrina Angermeyer, Andreas Borst, Sebastian Haferkamp, Claus-Jurgen Scholz, Marion Wobser, David Schrama, Roland Houben;
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=27402257; DOI=10.1002/pmic.201600223
Aelita Konstantinell, Jack-Ansgar Bruun, Randi Olsen, Augusta Aspar, Natasa Skalko-Basnet, Baldur Sveinbjornsson, Ugo Moens;
Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines.
Proteomics 16:2587-2591(2016)

PubMed=29696010; DOI=10.3389/fmicb.2018.00713; PMCID=PMC5905237
Celestino Velasquez, Yutaka Amako, Alexis Harold, Tuna Toptan, Yuan Chang, Masahiro Shuda;
Characterization of a Merkel cell polyomavirus-positive Merkel cell carcinoma cell line CVG-1.
Front. Microbiol. 9:713.1-713.10(2018)

PubMed=30873613; DOI=10.1002/ijc.32280
David Schrama, Eva-Maria Sarosi, Christian Adam, Cathrin Ritter, Ulrike Kaemmerer, Eva Klopocki, Eva-Maria Konig, Jochen Sven Utikal, Jurgen C. Becker, Roland Houben;
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z; PMCID=PMC6921584
Ulana Kotowski, Boban M. Erovic, Julia Schnoll, Victoria Stanek, Stefan Janik, Martin Steurer, Goran Mitulovic;
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Cross-references
Cell line collections (Providers) ECACC; 09111801
Cell line databases/resources Cell_Model_Passport; SIDM01791
DepMap; ACH-001122
CRISP screens repositories BioGRID_ORCS_Cell_line; 732
Encyclopedic resources Wikidata; Q54905813
Gene expression databases FANTOM5_SSTAR; 10843-111E6
Polymorphism and mutation databases Cosmic; 1693072
Cosmic; 1699817
Cosmic; 2273916
Proteomic databases PRIDE; PXD004198
PRIDE; PXD008181
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number22