ID   MKL-1
AC   CVCL_2600
SY   Mkl-1; MKL1
DR   BioGRID_ORCS_Cell_line; 732
DR   Cell_Model_Passport; SIDM01791
DR   Cosmic; 1693072
DR   Cosmic; 1699817
DR   Cosmic; 2273916
DR   DepMap; ACH-001122
DR   ECACC; 09111801
DR   PRIDE; PXD008181
DR   Wikidata; Q54905813
RX   PubMed=3546933;
RX   PubMed=10732753;
RX   PubMed=20444890;
RX   PubMed=22363598;
RX   PubMed=23085629;
RX   PubMed=23563200;
RX   PubMed=27121059;
RX   PubMed=29696010;
RX   PubMed=30873613;
RX   PubMed=31889939;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Virology: Contains 3.5 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
CC   Doubling time: ~120 hours (PubMed=3546933); 3 days (PubMed=20444890).
CC   Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
CC   Omics: Array-based CGH.
CC   Omics: Deep quantitative proteome analysis.
CC   Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): ECACC; PubMed=30873613
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,11
ST   D16S539: 10,12
ST   D18S51: 12,18
ST   D21S11: 30
ST   D3S1358: 15.2
ST   D5S818: 11,12
ST   D7S820: 8,11
ST   D8S1179: 10
ST   FGA: 21,25
ST   Penta D: 12,15
ST   Penta E: 10,14
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_ER19 ! MKL-1-FB
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 19
//
RX   PubMed=3546933;
RA   Rosen S.T., Gould V.E., Salwen H.R., Herst C.V., Le Beau M.M., Lee I.,
RA   Bauer K., Marder R.J., Andersen R., Kies M.S., Moll R., Franke W.W.,
RA   Radosevich J.A.;
RT   "Establishment and characterization of a neuroendocrine skin carcinoma
RT   cell line.";
RL   Lab. Invest. 56:302-312(1987).
//
RX   PubMed=10732753; DOI=10.1054/bjoc.1999.1006;
RA   Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M.,
RA   Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R.,
RA   De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.;
RT   "Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
RL   Br. J. Cancer 82:823-826(2000).
//
RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
//
RX   PubMed=22363598; DOI=10.1371/journal.pone.0031255;
RA   Hafner C., Houben R., Baeurle A., Ritter C., Schrama D.,
RA   Landthaler M., Becker J.C.;
RT   "Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
RL   PLoS ONE 7:E31255-E31255(2012).
//
RX   PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001;
RA   Guastafierro A., Feng H.-C., Thant M., Kirkwood J.M., Chang Y.,
RA   Moore P.S., Shuda M.;
RT   "Characterization of an early passage Merkel cell polyomavirus-positive
RT   Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma
RT   mice.";
RL   J. Virol. Methods 187:6-14(2013).
//
RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
//
RX   PubMed=27121059; DOI=10.18632/oncotarget.8793;
RA   Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A.,
RA   Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.;
RT   "RB1 is the crucial target of the Merkel cell polyomavirus Large T
RT   antigen in Merkel cell carcinoma cells.";
RL   Oncotarget 7:32956-32968(2016).
//
RX   PubMed=29696010; DOI=10.3389/fmicb.2018.00713;
RA   Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.;
RT   "Characterization of a Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell line CVG-1.";
RL   Front. Microbiol. 9:713.1-713.10(2018).
//
RX   PubMed=30873613; DOI=10.1002/ijc.32280;
RA   Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U.,
RA   Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.;
RT   "Characterization of six Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell lines: integration pattern suggest that large T antigen
RT   truncating events occur before or during integration.";
RL   Int. J. Cancer 145:1020-1032(2019).
//
RX   PubMed=31889939; DOI=10.1186/s12014-019-9263-z;
RA   Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M.,
RA   Mitulovic G.;
RT   "Quantitative proteome analysis of Merkel cell carcinoma cell lines
RT   using SILAC.";
RL   Clin. Proteomics 16:42.1-42.13(2019).
//