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Cellosaurus MCC26 (CVCL_2585)

[Text version]
Cell line name MCC26
Synonyms MCC26TC; MCC26 TC
Accession CVCL_2585
Resource Identification Initiative To cite this cell line use: MCC26 (RRID:CVCL_2585)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Karyotypic information: Hypotriploid karyotype.
Omics: Deep exome analysis.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 9884; RB1; Simple; p.Arg556Ter (c.1666C>T); ClinVar=VCV000013090; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.82
East Asian, North1.72
East Asian, South0
South Asian0
European, North66.7
European, South30.75
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): CBA; DepMap

Penta D12,14
Penta E11,14

Run an STR similarity search on this cell line

PubMed=10732753; DOI=10.1054/bjoc.1999.1006
Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M., Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R., De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=12209986; DOI=10.1002/ijc.10554
Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J., Speleman F., Sturm R.A.
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
Int. J. Cancer 101:103-110(2002)

PubMed=12209990; DOI=10.1002/ijc.10591
Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S., Cocquyt V., Salwen H.R., De Paepe A., Speleman F.
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=22363598; DOI=10.1371/journal.pone.0031255
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections CBA; CBA-1341
ECACC; 10092304
Cell line databases/resources Cell_Model_Passport; SIDM00006
Cosmic-CLP; 1298234
DepMap; ACH-001552
Biological sample resources BioSample; SAMN07624421
Chemistry resources GDSC; 1298234
PharmacoDB; MCC26_890_2019
Encyclopedic resources Wikidata; Q54904257
Polymorphism and mutation databases Cosmic; 912933
Cosmic; 1693076
Cosmic; 1699816
Cosmic; 2273915
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number25