ID   MCC26
AC   CVCL_2585
SY   MCC26TC; MCC26 TC
DR   BioSample; SAMN07624421
DR   cancercelllines; CVCL_2585
DR   CBA; CBA-1341
DR   Cell_Model_Passport; SIDM00006
DR   Cosmic; 912933
DR   Cosmic; 1693076
DR   Cosmic; 1699816
DR   Cosmic; 2273915
DR   Cosmic-CLP; 1298234
DR   DepMap; ACH-001552
DR   ECACC; 10092304
DR   GDSC; 1298234
DR   PharmacoDB; MCC26_890_2019
DR   Wikidata; Q54904257
RX   PubMed=10732753;
RX   PubMed=12209986;
RX   PubMed=12209990;
RX   PubMed=22363598;
RX   PubMed=23563200;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Karyotypic information: Hypotriploid karyotype.
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Arg556Ter (c.1666C>T); ClinVar=VCV000013090; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Genome ancestry: African=0%; Native American=0.82%; East Asian, North=1.72%; East Asian, South=0%; South Asian=0%; European, North=66.7%; European, South=30.75% (PubMed=30894373).
ST   Source(s): CBA; DepMap
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 13,14
ST   D16S539: 11,13
ST   D18S51: 15,18
ST   D19S433: 16
ST   D21S11: 31,32.2
ST   D2S1338: 23,26
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 8,9
ST   D8S1179: 8,10
ST   FGA: 24,25
ST   Penta D: 12,14
ST   Penta E: 11,14
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 26
//
RX   PubMed=10732753; DOI=10.1054/bjoc.1999.1006;
RA   Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M.,
RA   Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R.,
RA   De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.;
RT   "Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
RL   Br. J. Cancer 82:823-826(2000).
//
RX   PubMed=12209986; DOI=10.1002/ijc.10554;
RA   Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J.,
RA   Speleman F., Sturm R.A.;
RT   "Proneural and proneuroendocrine transcription factor expression in
RT   cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.";
RL   Int. J. Cancer 101:103-110(2002).
//
RX   PubMed=12209990; DOI=10.1002/ijc.10591;
RA   Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S.,
RA   Cocquyt V., Salwen H.R., De Paepe A., Speleman F.;
RT   "Combined karyotyping, CGH and M-FISH analysis allows detailed
RT   characterization of unidentified chromosomal rearrangements in Merkel
RT   cell carcinoma.";
RL   Int. J. Cancer 101:137-145(2002).
//
RX   PubMed=22363598; DOI=10.1371/journal.pone.0031255;
RA   Hafner C., Houben R., Baeurle A., Ritter C., Schrama D.,
RA   Landthaler M., Becker J.C.;
RT   "Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
RL   PLoS ONE 7:E31255-E31255(2012).
//
RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//