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Cellosaurus MCC14/2 (CVCL_2584)

[Text version]
Cell line name MCC14/2
Synonyms MCC14-2; MCC14/2TC; MCC14/2 TC; MCC142
Accession CVCL_2584
Resource Identification Initiative To cite this cell line use: MCC14/2 (RRID:CVCL_2584)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Deep exome analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Glu (c.815T>A); ClinVar=VCV000376673; Zygosity=Unspecified (PubMed=10732753; DepMap).
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Derived from metastatic site: Iliac lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4447 ! MCC14/1
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): CBA; DepMap

10,11 (DepMap)
D18S5112,15,17 (CBA)
15,17 (DepMap)
Penta D9,12
Penta E7

Run an STR similarity search on this cell line

PubMed=8026890; DOI=10.1002/ijc.2910580223
Thomson J.A.F., Leonard J.H., McGregor K., Sturm R.A., Parsons P.G.
A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines.
Int. J. Cancer 58:285-290(1994)

PubMed=7814141; DOI=10.1002/ijc.2910600115
Leonard J.H., Dash P., Holland P., Kearsley J.H., Bell J.R.
Characterisation of four Merkel cell carcinoma adherent cell lines.
Int. J. Cancer 60:100-107(1995)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006
Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M., Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R., De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=11433400; DOI=10.1002/ijc.1352
Cook A.L., Pollock P.M., Welch J., Walsh M.D., Bowman R.V., Baumann K.C., Hayward N.K., Leonard J.H.
CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.
Int. J. Cancer 93:361-367(2001)

PubMed=12209986; DOI=10.1002/ijc.10554
Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J., Speleman F., Sturm R.A.
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
Int. J. Cancer 101:103-110(2002)

Cell line collections CBA; CBA-1340
ECACC; 10092303
Cell line databases/resources Cell_Model_Passport; SIDM01360
DepMap; ACH-001551
Biological sample resources BioSample; SAMN07624420
Encyclopedic resources Wikidata; Q54904254
Polymorphism and mutation databases Cosmic; 912931
Cosmic; 2273914
IARC_TP53; 12478
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number19