ID   MCC14/2
AC   CVCL_2584
SY   MCC14-2; MCC14/2TC; MCC14/2 TC; MCC142
DR   BioSample; SAMN07624420
DR   cancercelllines; CVCL_2584
DR   CBA; CBA-1340
DR   Cell_Model_Passport; SIDM01360
DR   Cosmic; 912931
DR   Cosmic; 2273914
DR   DepMap; ACH-001551
DR   ECACC; 10092303
DR   IARC_TP53; 12478
DR   Wikidata; Q54904254
RX   PubMed=7814141;
RX   PubMed=8026890;
RX   PubMed=10732753;
RX   PubMed=11433400;
RX   PubMed=12209986;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val272Glu (c.815T>A); ClinVar=VCV000376673; Zygosity=Unspecified (PubMed=10732753; DepMap=ACH-001551).
CC   Omics: Deep exome analysis.
CC   Derived from site: Metastatic; Iliac lymph node; UBERON=UBERON_0015878.
ST   Source(s): CBA=CBA-1340; DepMap=ACH-001551
ST   Amelogenin: X
ST   CSF1PO: 10 (CBA=CBA-1340)
ST   CSF1PO: 10,11 (DepMap=ACH-001551)
ST   D13S317: 13
ST   D16S539: 13
ST   D18S51: 12,15,17 (CBA=CBA-1340)
ST   D18S51: 15,17 (DepMap=ACH-001551)
ST   D19S433: 12,14
ST   D21S11: 29,32.2
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 8,10
ST   D8S1179: 10,14
ST   FGA: 21
ST   Penta D: 9,12
ST   Penta E: 7
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_4447 ! MCC14/1
SX   Male
AG   80Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 22
//
RX   PubMed=7814141; DOI=10.1002/ijc.2910600115;
RA   Leonard J.H., Dash P., Holland P., Kearsley J.H., Bell J.R.;
RT   "Characterisation of four Merkel cell carcinoma adherent cell lines.";
RL   Int. J. Cancer 60:100-107(1995).
//
RX   PubMed=8026890; DOI=10.1002/ijc.2910580223;
RA   Thomson J.A.F., Leonard J.H., McGregor K., Sturm R.A., Parsons P.G.;
RT   "A nonconsensus octamer-recognition sequence (TAATGARAT-motif)
RT   identifies a novel DNA binding protein in human Merkel cell carcinoma
RT   cell lines.";
RL   Int. J. Cancer 58:285-290(1994).
//
RX   PubMed=10732753; DOI=10.1054/bjoc.1999.1006; PMCID=PMC2374386;
RA   Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M.,
RA   Geerts M.-L., Van Belle S., Cocquyt V., Bridge J.A., Sciot R.,
RA   De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.;
RT   "Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
RL   Br. J. Cancer 82:823-826(2000).
//
RX   PubMed=11433400; DOI=10.1002/ijc.1352;
RA   Cook A.L., Pollock P.M., Welch J., Walsh M.D., Bowman R.V.,
RA   Baumann K.C., Hayward N.K., Leonard J.H.;
RT   "CDKN2A is not the principal target of deletions on the short arm of
RT   chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.";
RL   Int. J. Cancer 93:361-367(2001).
//
RX   PubMed=12209986; DOI=10.1002/ijc.10554;
RA   Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J.,
RA   Speleman F., Sturm R.A.;
RT   "Proneural and proneuroendocrine transcription factor expression in
RT   cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.";
RL   Int. J. Cancer 101:103-110(2002).
//