ID   MCC14/2
AC   CVCL_2584
SY   MCC14-2; MCC14/2TC; MCC14/2 TC; MCC142
DR   BioSample; SAMN07624420
DR   cancercelllines; CVCL_2584
DR   CBA; CBA-1340
DR   Cell_Model_Passport; SIDM01360
DR   Cosmic; 912931
DR   Cosmic; 2273914
DR   DepMap; ACH-001551
DR   ECACC; 10092303
DR   IARC_TP53; 12478
DR   Wikidata; Q54904254
RX   PubMed=7814141;
RX   PubMed=8026890;
RX   PubMed=10732753;
RX   PubMed=10994482;
RX   PubMed=11433400;
RX   PubMed=12209986;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Glu (c.815T>A); ClinVar=VCV000376673; Zygosity=Unspecified (PubMed=10732753; DepMap=ACH-001551).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: Metastatic; Iliac lymph node; UBERON=UBERON_0015878.
ST   Source(s): CBA=CBA-1340; DepMap=ACH-001551
ST   Amelogenin: X
ST   CSF1PO: 10 (CBA=CBA-1340)
ST   CSF1PO: 10,11 (DepMap=ACH-001551)
ST   D13S317: 13
ST   D16S539: 13
ST   D18S51: 12,15,17 (CBA=CBA-1340)
ST   D18S51: 15,17 (DepMap=ACH-001551)
ST   D19S433: 12,14
ST   D21S11: 29,32.2
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 8,10
ST   D8S1179: 10,14
ST   FGA: 21
ST   Penta D: 9,12
ST   Penta E: 7
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_4447 ! MCC14/1
SX   Male
AG   80Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 25
//
RX   PubMed=7814141; DOI=10.1002/ijc.2910600115;
RA   Leonard, Joan Helen
RA   Dash, Peter
RA   Holland, Peter
RA   Kearsley, John Henry
RA   Bell, John R.
RT   "Characterisation of four Merkel cell carcinoma adherent cell lines.";
RL   Int. J. Cancer 60:100-107(1995).
//
RX   PubMed=10732753; DOI=10.1054/bjoc.1999.1006; PMCID=PMC2374386;
RA   Van Gele, Mireille
RA   Kaghad, Mourad
RA   Leonard, Joan Helen
RA   Van Roy, Nadine
RA   Naeyaert, Jean M.
RA   Geerts, Marie-Louise
RA   Van Belle, Simon
RA   Cocquyt, Veronique F.
RA   Bridge, Julia A.
RA   Sciot, Raf
RA   De Wolf-Peeters, Christiane
RA   De Paepe, Anne
RA   Caput, Daniel
RA   Speleman, Frank
RT   "Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
RL   Br. J. Cancer 82:823-826(2000).
//
RX   PubMed=11433400; DOI=10.1002/ijc.1352;
RA   Cook, Anthony L.
RA   Pollock, Pamela M.
RA   Welch, John
RA   Walsh, Michael D.
RA   Bowman, Rayleen V.
RA   Baumann, Kathryn C.
RA   Hayward, Nicholas K.
RA   Leonard, Joan Helen
RT   "CDKN2A is not the principal target of deletions on the short arm of
RT   chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.";
RL   Int. J. Cancer 93:361-367(2001).
//
RX   PubMed=8026890; DOI=10.1002/ijc.2910580223;
RA   Thomson, J. Angus F.
RA   Leonard, Joan Helen
RA   McGregor, K.
RA   Sturm, Richard A.
RA   Parsons, Peter G.
RT   "A nonconsensus octamer-recognition sequence (TAATGARAT-motif)
RT   identifies a novel DNA binding protein in human Merkel cell carcinoma
RT   cell lines.";
RL   Int. J. Cancer 58:285-290(1994).
//
RX   PubMed=10994482; DOI=10.1111/j.1440-0960.1997.tb01019.x;
RA   Leonard, Joan Helen
RA   Bell, John R.
RT   "Insights into the Merkel cell phenotype from Merkel cell carcinoma
RT   cell lines.";
RL   Australas. J. Dermatol. 38 Suppl. 1:S91-S98(1997).
//
RX   PubMed=12209986; DOI=10.1002/ijc.10554;
RA   Leonard, Joan Helen
RA   Cook, Anthony L.
RA   Van Gele, Mireille
RA   Boyle, Glen M.
RA   Inglis, Kelly J.
RA   Speleman, Frank
RA   Sturm, Richard A.
RT   "Proneural and proneuroendocrine transcription factor expression in
RT   cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.";
RL   Int. J. Cancer 101:103-110(2002).
//