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Cellosaurus J45.01 (CVCL_2530)

[Text version]
Cell line name J45.01
Accession CVCL_2530
Resource Identification Initiative To cite this cell line use: J45.01 (RRID:CVCL_2530)
Comments Population: Caucasian.
Characteristics: CD45-deficient.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814,17
D5S8189
D7S8208,9.3,10.3
D8S117914,15
D13S3178,11,12
D16S53911
D18S5113,21,22
D21S1131.2,33.2,34.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=1672451; DOI=10.1073/pnas.88.6.2037
Koretzky G.A., Picus J., Schultz T., Weiss A.
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.
Proc. Natl. Acad. Sci. U.S.A. 88:2037-2041(1991)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-1990
BCRC; 60255
ECACC; 93031145
Cell line databases/resources CLO; CLO_0006998
CLDB; cl2921
cancercelllines; CVCL_2530
LINCS_LDP; LCL-1029
Biological sample resources BioSample; SAMN03470881
Encyclopedic resources Wikidata; Q54898471
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number28