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Cellosaurus HMT-3522 T4-2 (CVCL_2501)

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Cell line name HMT-3522 T4-2
Synonyms T4-2; T4; HMT-3522/mt-1; mt-1; HMT-3522/massive tumor-1
Accession CVCL_2501
Resource Identification Initiative To cite this cell line use: HMT-3522 T4-2 (RRID:CVCL_2501)
Comments Part of: JWGray breast cancer cell line panel.
Population: Caucasian.
Doubling time: 32.94 hours (JWGray panel).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2500 (HMT-3522 S2)
Sex of cell Female
Age at sampling 50Y
Category Spontaneously immortalized cell line
STR profile Source(s): ECACC=98102212

Markers:
AmelogeninX
CSF1PO11,12
D5S8189,11
D7S8208,9
D13S31711
D16S53911,13
TH019,9.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=8616848
Per Briand, Kirsten Vang Nielsen, Mogens W. Madsen, Ole William Petersen;
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
Cancer Res. 56:2039-2044(1996)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Kristina Lorenz, Eva H. Lee, Mary Helen Barcellos-Hoff, Ole William Petersen, Joe W. Gray, Mina J. Bissell;
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225; PMCID=PMC2662716
Aylin Rizki, Valerie Marie Weaver, Sun-Young Lee, Gabriela I. Rozenberg, Koei Chin, Connie A. Myers, Jamie L. Bascom, Joni D. Mott, Jeremy R. Semeiks, Leslie Roy Grate, I. Saira Mian ...Show all 19 authors... , Alexander David Borowsky, Roy A. Jensen, Michael O. Idowu, Fan-Qing Chen, David J. Chen, Ole William Petersen, Joe W. Gray, Mina J. Bissell; Show fewer authors
A human breast cell model of preinvasive to invasive transition.
Cancer Res. 68:1378-1387(2008)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

Cross-references
Cell line collections (Providers) ECACC; 98102212
Cell line databases/resources cancercelllines; CVCL_2501
LINCS_HMS; 51123
Anatomy/cell type resources BTO; BTO_0006210
Chemistry resources PharmacoDB; T4_1558_2019
Encyclopedic resources Wikidata; Q54889970
Gene expression databases ArrayExpress; E-TABM-244
GEO; GSM1172999
GEO; GSM1219379
GEO; GSM1219380
GEO; GSM1219381
GEO; GSM1219382
GEO; GSM1219383
GEO; GSM1219384
GEO; GSM1219385
GEO; GSM1219386
GEO; GSM1219387
GEO; GSM1219388
GEO; GSM1219389
GEO; GSM1219390
GEO; GSM1219391
GEO; GSM1219392
GEO; GSM1219393
GEO; GSM1219394
GEO; GSM1219395
GEO; GSM1219396
GEO; GSM1219397
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22