Cellosaurus cell line FTC-236 (CVCL

Cellosaurus FTC-236 (CVCL_2446)

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Cell line name

FTC-236

Synonyms

FTC236

Accession

CVCL_2446

Resource Identification Initiative

To cite this cell line use: FTC-236 (RRID:CVCL_2446)

Comments

Population: Caucasian.
Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Transcriptomics; Microarray.
Misspelling: CFT-236; PubMed=1384245; Note=In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.

Sequence variations

Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Lys1045fs (c.3135delG); Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg130Ter (c.388C>T); ClinVar=VCV000007819; Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; HGNC:9884; RB1; Simple; p.Arg320Ter (c.958C>T); ClinVar=VCV000126824; Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=30737244).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=30737244).

Disease

Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_1219 ! FTC-133
CVCL_2447 ! FTC-238

Sex of cell

Male

Age at sampling

42Y

Category

Cancer cell line

STR profile

Source(s): ECACC=06030202; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	10,11
D3S1358	15,16
D5S818	11,12
D7S820	9,10
D8S1179	10
D13S317	11
D16S539	11,12
D18S51	11,12
D21S11	32.2
FGA	21
TH01	9.3
TPOX	9
vWA	15,18

Publications

PubMed=1384245; DOI=10.1007/BF02067383
Michael Joseph Demeure, Caroline H. Damsky, Fred Elfman, Peter E. Goretzki, Mariwil G. Wong, Orlo Herrick Clark;
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Willem E. Corver, Joris Demmers, Jan Oosting, Shima Sahraeian, Arnoud Boot, Dina Ruano, Tom van Wezel, Hans Morreau;
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=31443247; DOI=10.3390/cancers11081185; PMCID=PMC6721552
Mehtap Derya Aydemirli, Willem E. Corver, Ruben Beuk, Paul Roepman, Nienke Solleveld-Westerink, Tom van Wezel, Ellen H.W. Kapiteijn, Hans Morreau;
Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.
Cancers (Basel) 11:1185.1-1185.16(2019)

Cross-references

Cell line collections (Providers)

ECACC; 06030202

Cell line databases/resources

cancercelllines; CVCL_2446
Cell_Model_Passport; SIDM00229

Anatomy/cell type resources

BTO; BTO_0003875

Encyclopedic resources

Wikidata; Q54835218

Polymorphism and mutation databases

Cosmic; 1239977

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number