Cellosaurus logo
expasy logo

Cellosaurus FTC-133 (CVCL_1219)

[Text version]
Cell line name FTC-133
Synonyms FTC133
Accession CVCL_1219
Resource Identification Initiative To cite this cell line use: FTC-133 (RRID:CVCL_1219)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Anecdotal: Have been flown in space on Shenzhou-8 and on the ISS to study growth in microgravity (PubMed=23866977; PubMed=24196587; PubMed=25930030).
Misspelling: FTC-113; Cosmic=1889011.
Misspelling: CFT-133; PubMed=1384245; Note=In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*07:02,07:02
HLA-CC*07:02,07:02
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:01,06:01
HLA-DRDRB1*03:05
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.29
Native American1.18
East Asian, North4.32
East Asian, South0
South Asian0
European, North56.94
European, South36.26
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2446 ! FTC-236
CVCL_2447 ! FTC-238
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906864; ECACC=94060901; PubMed=18713817; PubMed=25877200; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10 (Cosmic-CLP=906864; ECACC=94060901; PubMed=25877200)
10,11 (PubMed=30737244)
D2S133820
D3S135815
D5S81811,12 (PubMed=30737244)
12 (Cosmic-CLP=906864; ECACC=94060901; PubMed=18713817; PubMed=25877200)
D7S8209,10 (Cosmic-CLP=906864; ECACC=94060901; PubMed=18713817; PubMed=30737244)
10 (PubMed=25877200)
D8S117910
D13S31711
D16S53911
D18S5111,12
D19S43312,13
D21S1132.2
FGA21
Penta D12
Penta E13
TH016.1,9.3 (PubMed=25877200)
9.3 (Cosmic-CLP=906864; ECACC=94060901; PubMed=30737244)
TPOX9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=2247845
Michael Joseph Demeure, Millie Elizabeth Hughes-Fulford, Peter E. Goretzki, Quan-Yang Duh, Orlo Herrick Clark;
Actin architecture of cultured human thyroid cancer cells: predictor of differentiation?
Surgery 108:986-993(1990)

PubMed=1726925
Hans Gerber, Hans-Jakob Peter, Lars Asmis, Hugo Studer;
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=1384245; DOI=10.1007/BF02067383
Michael Joseph Demeure, Caroline H. Damsky, Fred Elfman, Peter E. Goretzki, Mariwil G. Wong, Orlo Herrick Clark;
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

PubMed=14522906
Francesco Frasca, Veronica Vella, Alessandra Aloisi, Angelo Mandarino, Emanuela Mazzon, Riccardo Vigneri, Paolo Vigneri;
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
Wilma C.G. van Staveren, David Y. Weiss-Solis, Laurent Delys, Laurence Duprez, Guy Andry, Brigitte Franc, Gerry Thomas, Frederick Libert, Jacques-Emile Dumont, Vincent Detours, Carine Maenhaut;
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Rebecca E. Schweppe, Joshua P. Klopper, Christopher T. Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James Alexander Fagin, Laura A. Marlow, John Alton Copland 3rd, Robert Christian Smallridge, Bryan R. Haugen;
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787
Manuel Saiselet, Sebastien Floor, Maxime Tarabichi, Genevieve Dom, Aline Hebrant, Wilma C.G. van Staveren, Carine Maenhaut;
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=23866977; DOI=10.1016/j.biomaterials.2013.06.054
Jessica Pietsch, Xiao Ma, Markus Wehland, Ganna Aleshcheva, Achim Schwarzwalder, Jurgen Segerer, Maria Birlem, Astrid Horn, Johann Bauer, Manfred Infanger, Daniela Grimm;
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission.
Biomaterials 34:7694-7705(2013)

PubMed=24196587; DOI=10.1096/fj.13-243287
Xiao Ma, Jessica Pietsch, Markus Wehland, Herbert Schulz, Katrin Saar, Norbert Hubner, Johann Bauer, Markus Braun, Achim Schwarzwalder, Jurgen Segerer, Maria Birlem ...Show all 17 authors... , Astrid Horn, Ruth Hemmersbach, Kai Wasser, Jirka Grosse, Manfred Infanger, Daniela Grimm; Show fewer authors
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
FASEB J. 28:813-835(2014)

PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887
Christina A. von Roemeling, Laura A. Marlow, Anthony B. Pinkerton, Angela Crist, James Miller, Han W. Tun, Robert Christian Smallridge, John Alton Copland 3rd;
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
J. Clin. Endocrinol. Metab. 100:E697-E709(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25930030; DOI=10.1002/pmic.201500067
Stefan Riwaldt, Jessica Pietsch, Albert Sickmann, Johann Bauer, Markus Braun, Jurgen Segerer, Achim Schwarzwalder, Ganna Aleshcheva, Thomas Juhl Corydon, Manfred Infanger, Daniela Grimm;
Identification of proteins involved in inhibition of spheroid formation under microgravity.
Proteomics 15:2945-2952(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Willem E. Corver, Joris Demmers, Jan Oosting, Shima Sahraeian, Arnoud Boot, Dina Ruano, Tom van Wezel, Hans Morreau;
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=34445479; DOI=10.3390/ijms22168777; PMCID=PMC8395939
Daniela Melnik, Marcus Kruger, Herbert Schulz, Sascha Kopp, Markus Wehland, Johann Bauer, Bjorn Baselet, Randy Vermeesen, Sarah Baatout, Thomas Juhl Corydon, Manfred Infanger, Daniela Grimm;
The CellBox-2 mission to the International Space Station: thyroid cancer cells in space.
Int. J. Mol. Sci. 22:8777.1-8777.21(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 94060901
ICLC; HTL97015
Cell line databases/resources CLO; CLO_0003402
CLDB; cl1398
CLDB; cl1399
cancercelllines; CVCL_1219
CCRID; 1101HUM-PUMC000687
Cell_Model_Passport; SIDM00213
Cosmic-CLP; 906864
DepMap; ACH-000903
LINCS_LDP; LCL-1677
Anatomy/cell type resources BTO; BTO_0001889
Biological sample resources BioSample; SAMN03471027
BioSample; SAMN10987983
Chemistry resources ChEMBL-Cells; CHEMBL3308732
ChEMBL-Targets; CHEMBL1075445
GDSC; 906864
PharmacoDB; FTC133_368_2019
PubChem_Cell_line; CVCL_1219
Encyclopedic resources Wikidata; Q54835217
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827308
GEO; GSM887012
GEO; GSM888081
GEO; GSM1669794
Polymorphism and mutation databases Cosmic; 906864
Cosmic; 928831
Cosmic; 1239976
Cosmic; 1280044
Cosmic; 1507371
Cosmic; 1533556
Cosmic; 1536124
Cosmic; 1889011
Cosmic; 2054103
Cosmic; 2319848
Cosmic; 2791091
IARC_TP53; 21332
LiGeA; CCLE_543
Progenetix; CVCL_1219
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42