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Cellosaurus Ej138 (CVCL_2443)

[Text version]
Cell line name Ej138
Synonyms EJ138; EJ 138; MGH-U1; MGHU1; MGH-UI; MGH-U1 (EJ); EJ
Accession CVCL_2443
Resource Identification Initiative To cite this cell line use: Ej138 (RRID:CVCL_2443)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=3708594; PubMed=6823318; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00080.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00195.
Population: Caucasian; Swedish.
Doubling time: 20 hours (PubMed=3708594).
Omics: SNP array analysis.
Omics: Transcriptome analysis by ESTs sequencing.
Omics: Transcriptome analysis by microarray.
Derived from sampling site: Urinary bladder.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=864752; DOI=10.1093/jnci/58.6.1743
Marshall C.J., Franks L.M., Carbonell A.W.
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
J. Natl. Cancer Inst. 58:1743-1751(1977)

PubMed=870558; DOI=10.1177/25.4.870558
Benham F.J., Cottell D.C., Franks L.M., Wilson P.D.
Alkaline phosphatase activity in human bladder tumor cell lines.
J. Histochem. Cytochem. 25:266-274(1977)

PubMed=651066; DOI=10.5980/jpnjurol1928.69.1_40
Kato T., Ishikawa K., Nemoto R.
Morphologic characterization of two established cell lines, T24 and MGH-U1, derived from human bladder carcinoma.
Nihon Hinyokika Gakkai Zasshi 69:40-46(1978)

PubMed=663932; DOI=10.1620/tjem.124.33
Kato T., Ishikawa K., Nemoto R., Senoo A., Amano Y.
Morphological characterization of two established cell lines, T24 and MGH-U1, derived from human urinary bladder carcinoma.
Tohoku J. Exp. Med. 124:339-349(1978)

Williams R.D.
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=7185004; DOI=10.2302/kjm.31.127
Tachibana M.
Studies on cellular adhesiveness in five different culture cell lines derived from carcinoma of the urinary bladder.
Keio J. Med. 31:127-148(1982)

PubMed=6823318; DOI=10.1038/301429a0
O'Toole C.M., Povey S., Hepburn P.J., Franks L.M.
Identity of some human bladder cancer cell lines.
Nature 301:429-430(1983)

PubMed=6826254; DOI=10.1002/ijc.2910310308
Paulie S., Hansson Y., Lundblad M.-L., Perlmann P.
Lectins as probes for identification of tumor-associated antigens on urothelial and colonic carcinoma cell lines.
Int. J. Cancer 31:297-303(1983)

Lin C.-W., Lin J.C., Prout G.R. Jr.
Establishment and characterization of four human bladder tumor cell lines and sublines with different degrees of malignancy.
Cancer Res. 45:5070-5079(1985)

Masters J.R.W., Hepburn P.J., Walker L., Highman W.J., Trejdosiewicz L.K., Povey S., Parkar M., Hill B.T., Riddle P.R., Franks L.M.
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=2903891; DOI=10.1080/09553008814552341
Peacock J.H., Cassoni A.M., McMillan T.J., Steel G.G.
Radiosensitive human tumour cell lines may not be recovery deficient.
Int. J. Radiat. Biol. 54:945-953(1988)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23401075; DOI=10.1002/path.4176
Guo Y., Chekaluk Y., Zhang J., Du J., Gray N.S., Wu C.-L., Kwiatkowski D.J.
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
J. Pathol. 230:17-27(2013)

PubMed=25336970; DOI=10.2147/OTT.S69239
Yang P.-S., Hsu Y.-C., Lin Y.-H., Hou C.-P., Chen C.-L., Chang P.-L., Juang H.-H., Tsui K.-H.
The expression sequence tag is an effective method for screening DNA segments that predict urinary bladder transitional cell carcinoma prognosis.
Onco Targets Ther. 7:1777-1781(2014)

Cell line collections ECACC; 85061108
NCBI_Iran; C429
Cell line databases/resources CLO; CLO_0002905
CLO; CLO_0002906
CLDB; cl1152
CLDB; cl1154
Anatomy/cell type resources BTO; BTO:0003553
Biological sample resources BioSample; SAMN03151939
BioSample; SAMN03151949
Chemistry resources ChEMBL-Cells; CHEMBL3307583
ChEMBL-Targets; CHEMBL614292
PubChem_Cell_line; CVCL_2443
Encyclopedic resources Wikidata; Q54832176
Gene expression databases GEO; GSM827443
GEO; GSM1374473
Polymorphism and mutation databases Cosmic; 760480
Cosmic; 925828
Cosmic; 1093986
Cosmic; 1927289
Progenetix; CVCL_2443
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number31