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Cellosaurus COV362.4 (CVCL_2421)

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Cell line name COV362.4
Synonyms COV362-4; COV-362.4
Accession CVCL_2421
Resource Identification Initiative To cite this cell line use: COV362.4 (RRID:CVCL_2421)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Pro871fs (c.2611_2612ins1); Zygosity=Homozygous (PubMed=25230021).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.4095+1G>T; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=25230021).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=25230021).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2420 (COV362)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=07071904; PubMed=25230021; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133824,25
D3S135816,18
D5S81812,13 (PubMed=25877200)
13 (PubMed=25230021)
D7S82010,14
D8S117911
D13S31714
D16S53911
D18S5113
D19S43314
D21S1131,32.2
FGA24
Penta D9,11
Penta E7,11
TH019.3
TPOX11
vWA15,18

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Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415
Cornelia A.M. van den Berg-Bakker, Anne Hagemeijer, Elsa M. Franken-Postma, Vincent T.H.B.M. Smit, Peter J.K. Kuppen, Hedda H. van Ravenswaay Claasen, Cees J. Cornelisse, Peter I. Schrier;
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.
Int. J. Cancer 53:613-620(1993)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ECACC; 07071904
Cell line databases/resources cancercelllines; CVCL_2421
Cell_Model_Passport; SIDM01630
Biological sample resources BioSample; SAMN03473272
Encyclopedic resources Wikidata; Q54814343
Gene expression databases GEO; GSM313709
GEO; GSM1291134
Polymorphism and mutation databases Progenetix; CVCL_2421
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25